SCD1 inhibitor-3
Based on 1 Customer Validation
SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.24%
- No. CAS: 1282606-48-7
- Fòrmula: C19H16FN7O2
- Peso molecular:393.37
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Orally Active Compound Library
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Anti-Cancer Metabolism Compound Library
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Anti-Obesity Compound Library
HY-L087
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Lipid Metabolism Compound Library
HY-L091
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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High-Throughput Bioactive Compound Library
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Metabolism/Protease Compound Library
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Anti-Cancer Compound Library
HY-L025
Actividad biológica
SCD1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
103 nM
Compound: 17a
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Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs
Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs
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[PMID: 25555732] |
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis rats[1]
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Dosage:5 mg/kg
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Administration:P.o.; 4 hours
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Result:Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
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Animal Model:Lewis rats[1]
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Dosage:2~10 mg/kg
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Administration:P.o.; 4 hours
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Result:A dose-responsive reduction of plasma triglycerides desaturation index.
Chemical Information
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No. CAS 1282606-48-7
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Appearance Solid
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Peso molecular 393.37
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Fòrmula C19H16FN7O2
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Color White to off-white
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SMILES
O=C(C1=NNC(N2C=NN(CC3=CC=C(F)C=C3)C2=O)=C1)NCC4=CC=CN=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : ≥ 125 mg/mL (317.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5421 mL | 12.7107 mL | 25.4214 mL | 63.5534 mL |
| 5 mM | 0.5084 mL | 2.5421 mL | 5.0843 mL | 12.7107 mL | |
| 10 mM | 0.2542 mL | 1.2711 mL | 2.5421 mL | 6.3553 mL | |
| 15 mM | 0.1695 mL | 0.8474 mL | 1.6948 mL | 4.2369 mL | |
| 20 mM | 0.1271 mL | 0.6355 mL | 1.2711 mL | 3.1777 mL | |
| 25 mM | 0.1017 mL | 0.5084 mL | 1.0169 mL | 2.5421 mL | |
| 30 mM | 0.0847 mL | 0.4237 mL | 0.8474 mL | 2.1184 mL | |
| 40 mM | 0.0636 mL | 0.3178 mL | 0.6355 mL | 1.5888 mL | |
| 50 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2711 mL | |
| 60 mM | 0.0424 mL | 0.2118 mL | 0.4237 mL | 1.0592 mL | |
| 80 mM | 0.0318 mL | 0.1589 mL | 0.3178 mL | 0.7944 mL | |
| 100 mM | 0.0254 mL | 0.1271 mL | 0.2542 mL | 0.6355 mL |
SCD1 inhibitor-3 Related Classifications
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