SCD1 inhibitor-3
Based on 1 Customer Validation
SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer.
For research use only. We do not sell to patients.
- Purity: 98.24%
- CAS No.: 1282606-48-7
- Formula: C19H16FN7O2
- Molecular Weight:393.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-diabetic Compound Library
HY-L040
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Orally Active Compound Library
HY-L061
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Anti-Cancer Metabolism Compound Library
HY-L083
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Anti-Obesity Compound Library
HY-L087
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Lipid Metabolism Compound Library
HY-L091
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
SCD1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
103 nM
Compound: 17a
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Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs
Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs
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[PMID: 25555732] |
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis rats[1]
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Dosage:5 mg/kg
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Administration:P.o.; 4 hours
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Result:Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
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Animal Model:Lewis rats[1]
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Dosage:2~10 mg/kg
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Administration:P.o.; 4 hours
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Result:A dose-responsive reduction of plasma triglycerides desaturation index.
Chemical Information
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CAS No. 1282606-48-7
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Appearance Solid
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Molecular Weight 393.37
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Formula C19H16FN7O2
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Color White to off-white
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SMILES
O=C(C1=NNC(N2C=NN(CC3=CC=C(F)C=C3)C2=O)=C1)NCC4=CC=CN=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 125 mg/mL (317.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5421 mL | 12.7107 mL | 25.4214 mL | 63.5534 mL |
| 5 mM | 0.5084 mL | 2.5421 mL | 5.0843 mL | 12.7107 mL | |
| 10 mM | 0.2542 mL | 1.2711 mL | 2.5421 mL | 6.3553 mL | |
| 15 mM | 0.1695 mL | 0.8474 mL | 1.6948 mL | 4.2369 mL | |
| 20 mM | 0.1271 mL | 0.6355 mL | 1.2711 mL | 3.1777 mL | |
| 25 mM | 0.1017 mL | 0.5084 mL | 1.0169 mL | 2.5421 mL | |
| 30 mM | 0.0847 mL | 0.4237 mL | 0.8474 mL | 2.1184 mL | |
| 40 mM | 0.0636 mL | 0.3178 mL | 0.6355 mL | 1.5888 mL | |
| 50 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2711 mL | |
| 60 mM | 0.0424 mL | 0.2118 mL | 0.4237 mL | 1.0592 mL | |
| 80 mM | 0.0318 mL | 0.1589 mL | 0.3178 mL | 0.7944 mL | |
| 100 mM | 0.0254 mL | 0.1271 mL | 0.2542 mL | 0.6355 mL |
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