Acne

Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.

Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria.

Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ～65-fold and ～16-fold selectivitiy for the RARγ (EC₅₀=7.7 nM) over RARα (EC₅₀=500 nM) and RARβ (EC₅₀=125 nM), respectively.

Povorcitinib (INCB54707) is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP).

Androsterone glucuronide-d₄ (ADT-G-d₄) is the deuterated-labeled Androsterone glucuronide (HY-113104). Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne.

Androsterone glucuronide-d₅ (ADT-G-d₅) is the deuterated-labeled Androsterone glucuronide (HY-113104). Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne.

PF-07905428 is a topical acetyl-CoA carboxylase (ACC) inhibitor designed to minimize systemic exposure. PF-07905428 inhibits ACC, reduces sebaceous lipid production in the skin. PF-07905428 can be used for the research of acne vulgaris.

Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.

GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.

Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne.

Androsterone glucuronide-d₄ (ADT-G-d₄) sodium is the deuterated-labeled Androsterone glucuronide sodium (HY-113104A). Androsterone glucuronide (ADT-G) sodium is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide sodium levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide sodium can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne.

(Z)-Broparestrol is a prostaglandin synthetase inhibitor with an IC₅₀ of 7.0 μM in cattle. (Z)-Broparestrol inhibits prostaglandin synthetase activity in bovine seminal vesicle microsomes. (Z)-Broparestrol is applicable for acne-related research.