SCD1 inhibitor-1
Based on 1 Customer Validation
SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 1069094-65-0
- Formula: C21H22N3NaO3S2
- Molecular Weight:451.54
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Storage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 8.8 nM (Recombinant human SCD1 enzyme)[1]
SCD1 inhibitor-1 (1-10 mg/kg; oral administration; single dose) has an improved effect in high-sucrose rat models[1].
Pharmacokinetic Analysis in rat and mouse[1]
| Species | Route | Dose (mg/kg) | Cmax (μM) | tmax (h) | t1/2 (h) | AUC0-inf (μM·h) | BA (%) | Cltot (L/h/kg) |
| Rat | p.o. | 10 | 8.0 | 0.5 | 4.7 | 16.5 | 16 | / |
| Mouse | p.o. | 10 | 1.7 | 1.0 | 5.2 | 10.2 | 28 | / |
| Rat | i.v. | 1 | / | / | / | / | / | 0.21 |
| Mouse | i.v. | 1 | / | / | / | / | / | 0.61 |