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SynuClean-D (Synonyms: SC-D)

Cat. No.: HY-124876
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SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.

For research use only. We do not sell to patients.

SynuClean-D Chemical Structure

SynuClean-D Chemical Structure

CAS No. : 685121-45-3

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Description

SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease[1].

In Vitro

SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity[1].

In Vivo

The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1].

Molecular Weight

354.20

Formula

C₁₃H₅F₃N₄O₅

CAS No.

685121-45-3

SMILES

N#CC1=C(C(F)(F)F)C([N+]([O-])=O)=C(C2=CC=CC([N+]([O-])=O)=C2)NC1=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SynuClean-DSC-DOthersInhibitorinhibitorinhibit

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