SEC11C - SEC11 homolog C, signal peptidase complex subunit Gene

Also Known as SPC21; SPCS4C; SEC11L3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90701

About SEC11C

This gene has 8 transcripts (splice variants), 135 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 109.5), thyroid (RPKM 61.5) and 25 other tissues.

Summary

Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]

SEC11C Products (2)

mRNA	Protein	Name
NM_001307941.2	NP_001294870.1	signal peptidase complex catalytic subunit SEC11C isoform 2
NM_033280.4	NP_150596.1	signal peptidase complex catalytic subunit SEC11C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	34388369	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in signal peptide processing	IDA IDA: Inferred from direct assay	34388369	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	34388369	GOA
part of signal peptidase complex	IDA IDA: Inferred from direct assay	34388369	GOA
part of signal peptidase complex	IPI IPI: Inferred from physical interaction	34388369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC11C Protein Structure

Peptidase_S24

0
100
192 a.a.

Protein Preferred Names	Protein Names
signal peptidase complex catalytic subunit SEC11C	SEC11-like 3

SEC11C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEC11C	Q9BY50	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	SEC11C	Q9BY50	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	SEC11C	Q9BY50	TMEM128	Homo sapiens	Q5BJH2-2	Y2H Array	32296183
Intra	SEC11C	Q9BY50	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	SEC11C	Q9BY50	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	SEC11C	Q9BY50	SPCS3	Homo sapiens	P61009	3D-EM	34388369
Intra	SEC11C	Q9BY50	SPCS3	Homo sapiens	P61009	Anti Tag CoIP	34388369
Intra	SEC11C	Q9BY50	SPCS3	Homo sapiens	P61009	Anti Tag CoIP	33961781
Intra	SEC11C	Q9BY50	SPCS3	Homo sapiens	P61009	Anti Tag CoIP	28514442
Intra	SEC11C	Q9BY50	SPCS3	Homo sapiens	P61009	Crosslink	34388369
Intra	SEC11C	Q9BY50	SPCS3	Homo sapiens	P61009	SLCA	34388369
Intra	SEC11C	Q9BY50	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malignant Inflammatory Fibrous Histiocytoma	Inflammatory Mfh Xanthosarcoma
Malignant Iris Melanoma	Malignant Melanoma Of Iris Melanoma Of The Iris
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome	Mrxs13 Lindsay-Burn Syndrome Ppm-X Ppm-X Syndrome Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism Mental Retardation, X-Linked, Syndromic 13 X-Linked Mental Retardation 79 X-Linked Mental Retardation With Spasticity Intellectual Deficit, X-Linked - Psychosis - Macroorchidism Intellectual Disability Psychosis Macroorchidism Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism Intellectual Disability, X-Linked, Syndromic 13 Ppmx X-Linked Mental Retardation, Syndromic 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12604	SEC11C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SEC11C	RGD	RGD:628665
Canis familiaris	SEC11C	VGNC	VGNC:45961
Macaca mulatta	SEC11C	VGNC	VGNC:77295
Bos taurus	SEC11C	VGNC	VGNC:34402
Mus musculus	SEC11C	MGD	MGI:1913536
Others	SEC11C	NCBI