WIZ degrader 2
WIZ degrader 2 (Compound 142) is a molecular glue degrader for widely interspaced zinc (WIZ) finger motifs with an AC50 of 0.011 μM. WIZ degrader 2 induces the expression of fetal hemoglobin (HbF) with an EC50 of 0.038 μM. WIZ degrader 2 can be used in research related to hereditary blood disorders, such as sickle cell disease (SCD) and thalassemia.
For research use only. We do not sell to patients.
- CAS No.: 2839552-69-9
- Formula: C24H33N5O3
- Molecular Weight:439.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
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- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Description
In Vitro
Sickle cell disease (SCD) is a group of severe hereditary blood disorders that cause red blood cells to become distorted into a sickle shape. These cells can obstruct blood flow, leading to severe pain, organ damage, and premature death. β-thalassemia is a group of hereditary blood disorders caused by reduced or absent synthesis of β-globin, resulting in anemia. WIZ is widely expressed and plays a role in targeting G9a/GLP histone methyltransferases to genomic sites to regulate chromatin structure and transcription.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2839552-69-9
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Molecular Weight 439.55
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Formula C24H33N5O3
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SMILES
O=C(NC(CC1)=O)N1C(C=NN2C=C3)=C2C=C3C[C@H]4C[C@@H](N(CC4)CC5CCOCC5)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WIZ degrader 2 Related Classifications
HY-163818 Related Classifications
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