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Cat. No.: HY-114184

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MK-8245 analog

MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC₅₀ of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects.

For research use only. We do not sell to patients.

CAS No.: 1030612-87-3
Formula: C₁₆H₁₅BrFN₇O₃S
Molecular Weight:484.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MK-8245 analog Chemical Structure

CAS No.: 1030612-87-3

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC₅₀ of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects^[1].

IC₅₀ & Target

IC₅₀: 7 nM (rat SCD)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	189 nM Compound: 6	Inhibition of SCD-1 activity in Sprague-Dawley rat Hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting Inhibition of SCD-1 activity in Sprague-Dawley rat Hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 6	Inhibition of human delta6 desaturase activity expressed in human HEpG2 cells Inhibition of human delta6 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 6	Inhibition of rat delta-5 desaturase activity expressed in human HEpG2 cells Inhibition of rat delta-5 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 6	Inhibition of rat delta-6 desaturase activity expressed in human HEpG2 cells Inhibition of rat delta-6 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]
HepG2	IC₅₀	904 nM Compound: 6	Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 6	Inhibition of human delta-5 desaturase activity expressed in human HEpG2 cells Inhibition of human delta-5 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]

Chemical Information

CAS No. 1030612-87-3
Molecular Weight 484.30
Formula C₁₆H₁₅BrFN₇O₃S
SMILES

O=C(O)CN1N=C(C2=NN=C(N3CCC(OC4=CC(F)=CC=C4Br)CC3)S2)N=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Renata M Oballa, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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