2. Metabolic Enzyme/Protease
  3. Stearoyl-CoA Desaturase (SCD)
  4. YTX-465

YTX-465 

Cat. No.: HY-124751 Purity: 99.87%
COA Handling Instructions

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies.

For research use only. We do not sell to patients.

YTX-465 Chemical Structure

YTX-465 Chemical Structure

CAS No. : 2225824-53-1

Size Price Stock Quantity
1 mg USD 357 In-stock
5 mg USD 750 In-stock
10 mg USD 1200 In-stock
25 mg USD 2480 In-stock
50 mg USD 3950 In-stock
100 mg USD 6250 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

YTX-465 Related Antibodies

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Description

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies[1].

IC50 & Target[1]

Ole1

0.039 μM (IC50)

SCD1

30.4 μM (IC50)

In Vitro

YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue[1].
YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast[1].
YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop[1].
YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM[1].
YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YTX-465 Related Antibodies
Molecular Weight

458.51

Appearance

Solid

Formula

C25H26N6O3
CAS No.
SMILES

O=C(NCC(N1CCC(C2=NC(C3=CC4=C(C=C3)C(C)=NN4C)=NO2)CC1)=O)C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (218.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1810 mL 10.9049 mL 21.8098 mL
5 mM 0.4362 mL 2.1810 mL 4.3620 mL
10 mM 0.2181 mL 1.0905 mL 2.1810 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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YTX-465 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

YTX-4652225824-53-1YTX465YTX 465Stearoyl-CoA Desaturase (SCD)Parkinson’s diseasesynucleinopathiesα-synucleinα-Syn-expressing yeastfatty desaturationInhibitorinhibitorinhibit

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