1. Metabolic Enzyme/Protease
  2. Stearoyl-CoA Desaturase (SCD)
  3. YTX-465

YTX-465 

Cat. No.: HY-124751 Purity: 99.87%
Handling Instructions

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies.

For research use only. We do not sell to patients.

YTX-465 Chemical Structure

YTX-465 Chemical Structure

CAS No. : 2225824-53-1

Size Price Stock Quantity
5 mg USD 750 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 6250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies[1].

IC50 & Target[1]

Ole1

0.039 μM (IC50)

SCD1

30.4 μM (IC50)

In Vitro

YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue[1].
YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast[1].
YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop[1].
YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM[1].
YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

458.51

Formula

C25H26N6O3

CAS No.
SMILES

O=C(NCC(N1CCC(C2=NC(C3=CC4=C(C=C3)C(C)=NN4C)=NO2)CC1)=O)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (218.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1810 mL 10.9049 mL 21.8098 mL
5 mM 0.4362 mL 2.1810 mL 4.3620 mL
10 mM 0.2181 mL 1.0905 mL 2.1810 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.45 mM); Clear solution

*All of the co-solvents are available by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
YTX-465
Cat. No.:
HY-124751
Quantity:
MCE Japan Authorized Agent: