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Cat. No.: HY-155209

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SCD1 inhibitor-5

SCD1 inhibitor-5 (compound 51) is a SCD1 inhibitor,with the IC₅₀ values of 0.13 μM and 31 μM for H2122 and H1819, respectively. SCD1 inhibitor-5 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1673558-59-2
Formula: C₂₅H₁₈N₂O₄S
Molecular Weight:442.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

SCD1 inhibitor-5 Chemical Structure

CAS No.: 1673558-59-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Biological Activity

Description

SCD1 inhibitor-5 (compound 51) is a SCD1 inhibitor,with the IC₅₀ values of 0.13 μM and 31 μM for H2122 and H1819, respectively. SCD1 inhibitor-5 can be used in cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H2122	IC₅₀	0.13 μM Compound: 51	Inhibition of SCD in human NCI-H2122 cells expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay Inhibition of SCD in human NCI-H2122 cells expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay	[PMID: 32787093]

Chemical Information

CAS No. 1673558-59-2
Molecular Weight 442.49
Formula C₂₅H₁₈N₂O₄S
SMILES

O=C(C1=CC=C(C(C2=CC=C(C=C2)OCC#C)=O)C=C1)NC3=NC4=C(S3)C=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Williams NS, et al. Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase. J Med Chem. 2020 Sep 10;63(17):9773-9786. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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SCD1 inhibitor-5

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SCD1 inhibitor-5 Related Classifications

HY-155209 Related Classifications