PF-07059013
Based on 1 publication(s) in Google Scholar
PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2435610-93-6
- 分子式: C19H16FN5O2
- 分子量:365.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 PF-07059013
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生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Townes SCD mice (8-10 weeks old, male)[1]
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Dosage:10, 40, 200, and 490 mg/kg
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Administration:Oral gavage, twice daily, for 2 weeks
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Result:Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2435610-93-6
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分子量 365.36
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分子式 C19H16FN5O2
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SMILES
NC1=NC(C=CC(F)=C2)=C2C=C1O[C@H](C3=C(N4C=CC=N4)C=CC(N3)=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PF-07059013 関連分類
HY-139293 関連分類
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