2. Gene
  3. SPAG4 - sperm associated antigen 4 Gene

SPAG4 - sperm associated antigen 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SUN4; CT127

Gene ID: 6676 | Gene type: protein coding

About SPAG4

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,615,829-35,621,094 (from NCBI)

This gene has 8 transcripts (splice variants), 107 orthologues and 4 paralogues. Broad expression in testis (RPKM 8.6), pancreas (RPKM 6.3) and 20 other tissues.

Summary

The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

SPAG4 Products(2)

mRNA Protein Name
NM_001317931.1 NP_001304860.1 sperm-associated antigen 4 protein isoform 2
NM_003116.3 NP_003107.1 sperm-associated antigen 4 protein isoform 1

SPAG4 Protein Structure

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (292 - 423)

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  • 437 a.a.
Protein Preferred Names Protein Names

sperm-associated antigen 4 protein

SUN domain-containing protein 4

Related Diseases

Diseases Alias
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13623 SPAG4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPAG4 VGNC VGNC:77850
Rattus norvegicus SPAG4 RGD RGD:620151
Felis catus SPAG4 VGNC VGNC:65596
Mus musculus SPAG4 MGD MGI:2444120
Canis familiaris SPAG4 VGNC VGNC:54733
Bos taurus SPAG4 VGNC VGNC:35166