SEPTIN12 - septin 12 Gene

Also Known as SEPT12; SPGF10

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 124404

Summary

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SEPTIN12 Products (1)

mRNA Protein Name
XM_054379608.1 XP_054235583.1 septin-12 isoform X3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
18443421 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25588830 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18047794 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
18443421 GOA
Cellular Component GO Annotation Evidence References Source
located in midbody IDA
IDA: Inferred from direct assay
18047794 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18047794 GOA
part of septin complex IDA
IDA: Inferred from direct assay
25588830 GOA
located in sperm annulus IDA
IDA: Inferred from direct assay
22275165 GOA
located in spindle IDA
IDA: Inferred from direct assay
18047794 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

septin-12

  • testicular tissue protein Li 168

SEPTIN12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEPTIN12 Q8IYM1 SEPTIN4 Homo sapiens O43236
Anti Tag CoIP
33961781
Intra
SEPTIN12 Q8IYM1 SEPTIN4 Homo sapiens O43236
Y2H
25775403
Intra
SEPTIN12 Q8IYM1 SEPTIN4 Homo sapiens O43236
IF
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN4 Homo sapiens O43236
Anti Tag CoIP
25588830
Intra
SEPTIN12 Q8IYM1 SPAG4 Homo sapiens Q9NPE6
Imaging
25775403
Intra
SEPTIN12 Q8IYM1 SPAG4 Homo sapiens Q9NPE6
Anti Tag CoIP
25775403
Intra
SEPTIN12 Q8IYM1 SPAG4 Homo sapiens Q9NPE6
IF
25775403
Intra
SEPTIN12 Q8IYM1 SPAG4 Homo sapiens Q9NPE6
Y2H
25775403
Intra
SEPTIN12 Q8IYM1 SEPTIN7 Homo sapiens Q16181
Anti Tag CoIP
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN7 Homo sapiens Q16181
IF
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN7 Homo sapiens Q16181
Anti Tag CoIP
33961781
Intra
SEPTIN12 Q8IYM1 SEPTIN6 Homo sapiens Q14141
Anti Tag CoIP
33961781
Intra
SEPTIN12 Q8IYM1 SEPTIN6 Homo sapiens Q14141
Anti Tag CoIP
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN6 Homo sapiens Q14141
Y2H
25775403
Intra
SEPTIN12 Q8IYM1 SEPTIN6 Homo sapiens Q14141
IF
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN5 Homo sapiens Q99719
Anti Tag CoIP
33961781
Intra
SEPTIN12 Q8IYM1 SEPTIN5 Homo sapiens Q99719
Validated Y2H
32296183
Intra
SEPTIN12 Q8IYM1 SEPTIN1 Homo sapiens Q8WYJ6
Validated Y2H
25416956
Intra
SEPTIN12 Q8IYM1 SEPTIN1 Homo sapiens Q8WYJ6
Y2H Prey Pooling
25416956
Intra
SEPTIN12 Q8IYM1 SEPTIN1 Homo sapiens Q8WYJ6
Validated Y2H
32296183
Intra
SEPTIN12 Q8IYM1 SEPTIN1 Homo sapiens Q8WYJ6
Anti Tag CoIP
31515488
Intra
SEPTIN12 Q8IYM1 SEPTIN2 Homo sapiens Q15019
Anti Tag CoIP
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN2 Homo sapiens Q15019
IF
25588830
Intra
SEPTIN12 Q8IYM1 SEPTIN2 Homo sapiens Q15019
Anti Tag CoIP
33961781
Intra
SEPTIN12 Q8IYM1 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12682 SEPTIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12681 SEPTIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown