SEPTIN7 - septin 7 Gene

Also Known as CDC3; CDC10; SEPT7; SEPT7A; NBLA02942

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 989

About SEPTIN7

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:35,800,986-35,915,763 (from NCBI)

This gene has 19 transcripts (splice variants), 236 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 77.8), lymph node (RPKM 34.7) and 24 other tissues.

Summary

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

SEPTIN7 Products (5)

mRNA	Protein	Name
NM_001011553.4	NP_001011553.2	septin-7 isoform 2
NM_001242956.1	NP_001229885.1	septin-7 isoform 3
NM_001363715.2	NP_001350644.1	septin-7 isoform 4
NM_001375299.1	NP_001362228.1	septin-7 isoform 4
NM_001788.6	NP_001779.3	septin-7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22064074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11584266	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	23572511	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axoneme	IDA IDA: Inferred from direct assay	23572511	GOA
located in non-motile cilium	IDA IDA: Inferred from direct assay	23572511	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15485874	GOA
part of septin complex	IDA IDA: Inferred from direct assay	15485874	GOA
located in sperm annulus	IDA IDA: Inferred from direct assay	25588830	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	15485874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEPTIN7 Protein Structure

Septin

0
100
200
300
400
436 a.a.

Protein Preferred Names	Protein Names
septin-7	CDC10 (cell division cycle 10, S. cerevisiae, homolog)

SEPTIN7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEPTIN7	Q16181	SEPTIN11	Homo sapiens	Q9NVA2	Anti Tag CoIP	33961781
Intra	SEPTIN7	Q16181	SEPTIN6	Homo sapiens	Q14141	Crosslink	30021884
Intra	SEPTIN7	Q16181	SEPTIN11	Homo sapiens	Q9NVA2	Crosslink	30021884
Intra	SEPTIN7	Q16181	SEPTIN6	Homo sapiens	Q14141	Pull Down	24633326
Intra	SEPTIN7	Q16181	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	35271311
Intra	SEPTIN7	Q16181	SEPTIN6	Homo sapiens	Q14141	Pull Down	17637674
Intra	SEPTIN7	Q16181	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	33961781
Intra	SEPTIN7	Q16181	SEPTIN12	Homo sapiens	Q8IYM1	Y2H Array	31515488
Intra	SEPTIN7	Q16181	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	35271311
Intra	SEPTIN7	Q16181	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	33961781
Intra	SEPTIN7	Q16181	SEPTIN10	Homo sapiens	Q9P0V9	Anti Tag CoIP	33961781
Intra	SEPTIN7	Q16181	SEPTIN9	Homo sapiens	Q9UHD8	Anti Tag CoIP	33961781
Intra	SEPTIN7	Q16181	SEPTIN9	Homo sapiens	Q9UHD8	Anti Tag CoIP	35271311
Intra	SEPTIN7	Q16181	SEPTIN8	Homo sapiens	Q92599	Anti Tag CoIP	33961781
Intra	SEPTIN7	Q16181	SEPTIN8	Homo sapiens	Q92599	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

SEPTIN7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82182	Septin 7 Antibody (YA1927)	WB, ICC/IF	Human, Mouse, Rat
HY-P82182A	Septin 7 Antibody (YA1927)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Amyotrophic Neuralgia	Neuralgic Amyotrophy Brachial Plexus Neuritis Neuralgic Shoulder Amyotrophy Acute Brachial Plexus Neuritis Immune Brachial Plexus Neuropathy Mononeuritis Multiplex With Brachial Predilection Parsonage-Turner Syndrome
Brachial Plexus Neuropathy	Brachial Plexopathy Brachial Plexus Neuropathies Brachial Plexus Disorder Bpn - [Brachial Plexus Neuropathy] Brachial Plexus Disease Neuropathic Plexus Brachialis Brachial Plexus Syndrome Brachial Plexus Irritation Brachial Plexus Lesion Brachial Plexus Pressure Compression Of Brachial Plexus
Epidural Spinal Canal Neoplasm	Extradural Tumor Epidural Neoplasms Epidural Neoplasm
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly	MARCH Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia And Hydranencephaly Multinucleated Neurons-Anhydramnios-Renal Dysplasia-Cerebellar Hypoplasia-Hydranencephaly Syndrome Hydranencephaly With Renal Aplasia-Dysplasia March Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12684	SEPTIN7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEPTIN7	VGNC	VGNC:53670
Macaca mulatta	SEPTIN7	VGNC	VGNC:81759
Felis catus	SEPTIN7	VGNC	VGNC:65014
Rattus norvegicus	SEPTIN7	RGD	RGD:620469
Mus musculus	SEPTIN7	MGD	MGI:1335094
Canis familiaris	SEPTIN7	VGNC	VGNC:46016
Others	SEPTIN7	NCBI