SEPTIN8 - septin 8 Gene

Also Known as SEP2; SEPT8; Septin-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23176

Summary

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Ubiquitous expression in brain (RPKM 43.2), urinary bladder (RPKM 16.3) and 22 other tissues.

SEPTIN8 Products (6)

mRNA Protein Name
NM_001098811.2 NP_001092281.1 septin-8 isoform a
NM_001098812.2 NP_001092282.1 septin-8 isoform c
NM_001098813.2 NP_001092283.1 septin-8 isoform d
NM_001300798.2 NP_001287727.1 septin-8 isoform e
NM_001300799.2 NP_001287728.1 septin-8 isoform f
NM_015146.2 NP_055961.1 septin-8 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
15214843 GOA
Biological Process GO Annotation Evidence Références Source
involved in regulation of intracellular protein transport IDA
IDA: Inferred from direct assay
27084579 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
27084579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEPTIN8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SEPTIN8 Q92599 SEPTIN7 Homo sapiens Q16181
Anti Tag CoIP
35271311
Intra
SEPTIN8 Q92599 SEPTIN7 Homo sapiens Q16181
Crosslink
30021884
Intra
SEPTIN8 Q92599 SEPTIN5 Homo sapiens Q99719
IF
15214843
Intra
SEPTIN8 Q92599 SEPTIN5 Homo sapiens Q99719
Anti Bait CoIP
15214843
Intra
SEPTIN8 Q92599 SEPTIN5 Homo sapiens Q99719
Anti Tag CoIP
35271311
Intra
SEPTIN8 Q92599 SEPTIN5 Homo sapiens Q99719
Y2H
15214843
Intra
SEPTIN8 Q92599 SEPTIN5 Homo sapiens Q99719
Y2H
16767699
Cross: Cross-species interaction Intra: Intraspecies interaction

SEPTIN8 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83489 Septin 8 Antibody (YA3234) WB, IP Hamster, Rat
HY-P83489A Septin 8 Antibody (YA3234)(PBS only) WB, IP Hamster, Rat