Septin 8 Antibody (YA3234)
(Synonyms: SEP2; SEPT8)Septin 8 Antibody (YA3234) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Septin 8.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Hamster, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
Septin 8 Antibody (YA3234) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Septin 8.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHamster, Rat
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Observed Molecular WeightObserved band size: 56 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 56 kDa
Entrez Gene: 23176 Human ; 20362 Mouse ;
SwissProt: Q92599 Human ; Q8CHH9 Mouse ; B0BNF1 Rat
OMIM: 608418 Human
A synthetic peptide of human Septin 8 aa64-77.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Septin 8 is a Filament-forming cytoskeletal GTPase. May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles; Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP[1].
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Synapse; Cell projection, axon; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Presynapse
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Expression
Tissue_specificity:Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary -
Isoforms & Post-Translational Modification
Q92599 has 4 isomers: Q92599-1: 55756 Da (predicted); Q92599-2: 49814 Da (predicted); Q92599-3: 43519 Da (predicted); Q92599-4: 51178 Da (predicted).
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Subunit
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules.
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SwissProt ID
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Synonyms
SEP2; SEPT8
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Research Field
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Documentation
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