RNF5 - ring finger protein 5 Gene
Also Known as RMA1; RING5
Species: Homo sapiens
About RNF5
This gene has 2 transcripts (splice variants), 1 gene allele, 185 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 45.9), small intestine (RPKM 33.9) and 25 other tissues.
Summary
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin Ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]
RNF5 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_006913.4 | NP_008844.1 | E3 ubiquitin-protein ligase RNF5 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12861019 | GOA |
| enables protein-containing complex binding |
IPI
IPI: Inferred from physical interaction
|
24019521 | GOA |
| enables ubiquitin-protein transferase activity |
IDA
IDA: Inferred from direct assay
|
19269966 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in ERAD pathway |
IMP
IMP: Inferred from mutant phenotype
|
19269966 | GOA |
| involved in protein K48-linked ubiquitination |
IDA
IDA: Inferred from direct assay
|
19285439 | GOA |
| involved in protein K63-linked ubiquitination |
IDA
IDA: Inferred from direct assay
|
19269966 | GOA |
| involved in protein catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
19285439 | GOA |
| involved in ubiquitin-dependent protein catabolic process |
IGI
IGI: Inferred from genetic interaction
|
24019521 | GOA |
RNF5 Protein Structure
zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (27 - 67)
- 0
- 100
- 180 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
E3 ubiquitin-protein ligase RNF5 |
|
RNF5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
RNF5 | Q99942 | UBE2W | Homo sapiens | Q96FI0 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2W | Homo sapiens | Q96FI0 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | SLC38A7 | Homo sapiens | Q9NVC3 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | SLC38A7 | Homo sapiens | Q9NVC3 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | TMEM242 | Homo sapiens | Q9NWH2 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | ORMDL1 | Homo sapiens | Q9P0S3 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | UBE2E2 | Homo sapiens | Q96LR5 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2E2 | Homo sapiens | Q96LR5 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2E2 | Homo sapiens | Q96LR5 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | RNF185 | Homo sapiens | Q96GF1 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | RNF185 | Homo sapiens | Q96GF1 | 33961781 | |
|
Intra
|
RNF5 | Q99942 | RNF185 | Homo sapiens | Q96GF1 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | RNF185 | Homo sapiens | Q96GF1 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2D2 | Homo sapiens | P62837 | 14667819 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 19549727 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 14667819 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2D3 | Homo sapiens | P61077 | 19549727 | |
|
Intra
|
RNF5 | Q99942 | UBE2E3 | Homo sapiens | Q969T4 | 14667819 | |
|
Intra
|
RNF5 | Q99942 | UBE2E3 | Homo sapiens | Q969T4 | 31515488 | |
|
Intra
|
RNF5 | Q99942 | UBE2E3 | Homo sapiens | Q969T4 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2E3 | Homo sapiens | Q969T4 | 19549727 | |
|
Intra
|
RNF5 | Q99942 | ABHD16A | Homo sapiens | O95870 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | ABHD16A | Homo sapiens | O95870 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | CFTR | Homo sapiens | P13569 | 16901789 | |
|
Intra
|
RNF5 | Q99942 | SLC1A5 | Homo sapiens | Q15758 | 25759021 | |
|
Intra
|
RNF5 | Q99942 | SLC1A5 | Homo sapiens | Q15758 | 25759021 | |
|
Intra
|
RNF5 | Q99942 | UBE2K | Homo sapiens | P61086 | 32814053 | |
|
Intra
|
RNF5 | Q99942 | UBE2K | Homo sapiens | P61086 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2K | Homo sapiens | P61086 | 32814053 | |
|
Intra
|
RNF5 | Q99942 | UBE2K | Homo sapiens | P61086 | 32814053 | |
|
Intra
|
RNF5 | Q99942 | UBE2K | Homo sapiens | P61086 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | PXN | Homo sapiens | P49023 | 12861019 | |
|
Intra
|
RNF5 | Q99942 | PXN | Homo sapiens | P49023 | 12861019 | |
|
Intra
|
RNF5 | Q99942 | RABAC1 | Homo sapiens | Q9UI14 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | UBE2W | Homo sapiens | Q96B02 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2W | Homo sapiens | Q96B02 | 19549727 | |
|
Intra
|
RNF5 | Q99942 | SLC38A2 | Homo sapiens | Q96QD8 | 25759021 | |
|
Intra
|
RNF5 | Q99942 | SLC38A2 | Homo sapiens | Q96QD8 | 25759021 | |
|
Intra
|
RNF5 | Q99942 | UBE2D1 | Homo sapiens | P51668 | 19549727 | |
|
Intra
|
RNF5 | Q99942 | UBE2D1 | Homo sapiens | P51668 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2D1 | Homo sapiens | P51668 | 19549727 | |
|
Intra
|
RNF5 | Q99942 | UBE2D1 | Homo sapiens | P51668 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | SLC1A1 | Homo sapiens | P43005 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | SLC1A1 | Homo sapiens | P43005 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBE2D4 | Homo sapiens | Q9Y2X8 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | UBE2D4 | Homo sapiens | Q9Y2X8 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | UBTD1 | Homo sapiens | Q9HAC8 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
RNF5 | Q99942 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
RNF5 | Q99942 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
RNF5 | Q99942 | YIPF2 | Homo sapiens | Q9BWQ6 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | YIPF2 | Homo sapiens | Q9BWQ6 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | YIPF2 | Homo sapiens | Q9BWQ6 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | YIPF4 | Homo sapiens | Q9BSR8 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | YIPF1 | Homo sapiens | Q9Y548 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | INSIG2 | Homo sapiens | Q9Y5U4 | 32296183 | |
|
Intra
|
RNF5 | Q99942 | INSIG2 | Homo sapiens | Q9Y5U4 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | CYB561 | Homo sapiens | P49447 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | CYB561 | Homo sapiens | P49447 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | CYB561 | Homo sapiens | P49447 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | SEC22A | Homo sapiens | Q96IW7 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | SEC22A | Homo sapiens | Q96IW7 | 25416956 | |
|
Intra
|
RNF5 | Q99942 | RHBDD1 | Homo sapiens | Q8TEB9 | 33961781 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cystic Fibrosis |
|
|
| Inflammatory Bowel Disease 7 |
|
|
| Herpes Simplex Virus Keratitis |
|
|
| Phosphoglycerate Dehydrogenase Deficiency |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | RNF5 | VGNC | VGNC:76706 |
| Bos taurus | RNF5 | VGNC | VGNC:34070 |
| Felis catus | RNF5 | VGNC | VGNC:64705 |
| Canis familiaris | RNF5 | VGNC | VGNC:45673 |
| Rattus norvegicus | RNF5 | RGD | RGD:1588458 |
| Mus musculus | RNF5 | MGD | MGI:1860076 |
| Others | RNF5 | NCBI |