RNF5 - ring finger protein 5 Gene

Homo sapiens

Also known as RMA1; RING5

Gene ID: 6048 | Gene type: protein coding

About RNF5

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,178,405-32,180,793 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 185 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 45.9), small intestine (RPKM 33.9) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

RNF5 Products(1)

mRNA	Protein	Name
NM_006913.4	NP_008844.1	E3 ubiquitin-protein ligase RNF5

RNF5 Protein Structure

zf-C3HC4_2

0
100
180 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF5

RING-type E3 ubiquitin transferase RNF5

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Inflammatory Bowel Disease 7

IBD7

Herpes Simplex Virus Keratitis

Dendritic Keratitis	Keratitis, Dendritic
Keratitis, Herpetic

Phosphoglycerate Dehydrogenase Deficiency

Phgdh Deficiency	3-Phosphoglycerate Dehydrogenase Deficiency
PHGDHD	3-Pgdh Deficiency
3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form	Phgdh Deficiency, Infantile/Juvenile Form
Deficiency, Phosphoglycerate Dehydrogenase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123967	RNF5 inhibitor inh-02		99.81%	Unkown
HY-RS12094	RNF5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF5	VGNC	VGNC:76706
Bos taurus	RNF5	VGNC	VGNC:34070
Felis catus	RNF5	VGNC	VGNC:64705
Canis familiaris	RNF5	VGNC	VGNC:45673
Rattus norvegicus	RNF5	RGD	RGD:1588458
Mus musculus	RNF5	MGD	MGI:1860076
Others	RNF5	NCBI

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