RNF5 inhibitor inh-02

Cat. No.: HY-123967 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC₅₀=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research.

For research use only. We do not sell to patients.

RNF5 inhibitor inh-02 Chemical Structure

CAS No. : 324579-65-9

Size	Price	Stock	Quantity
5 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

384.50

Formula

C₂₃H₂₀N₄S

CAS No.

324579-65-9

Appearance

Solid

Color

White to yellow

SMILES

CC1=NS/C(N1CC2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (216.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6008 mL	13.0039 mL	26.0078 mL
5 mM	0.5202 mL	2.6008 mL	5.2016 mL
10 mM	0.2601 mL	1.3004 mL	2.6008 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.81%

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Data Sheet (275 KB) SDS (0 KB)

COA (257 KB) HNMR (139 KB) RP-HPLC (140 KB) LCMS (257 KB)

Handling Instructions (2659 KB)

References

[1]. Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6008 mL	13.0039 mL	26.0078 mL	65.0195 mL
	5 mM	0.5202 mL	2.6008 mL	5.2016 mL	13.0039 mL
	10 mM	0.2601 mL	1.3004 mL	2.6008 mL	6.5020 mL
	15 mM	0.1734 mL	0.8669 mL	1.7339 mL	4.3346 mL
	20 mM	0.1300 mL	0.6502 mL	1.3004 mL	3.2510 mL
	25 mM	0.1040 mL	0.5202 mL	1.0403 mL	2.6008 mL
	30 mM	0.0867 mL	0.4335 mL	0.8669 mL	2.1673 mL
	40 mM	0.0650 mL	0.3251 mL	0.6502 mL	1.6255 mL
	50 mM	0.0520 mL	0.2601 mL	0.5202 mL	1.3004 mL
	60 mM	0.0433 mL	0.2167 mL	0.4335 mL	1.0837 mL
	80 mM	0.0325 mL	0.1625 mL	0.3251 mL	0.8127 mL
	100 mM	0.0260 mL	0.1300 mL	0.2601 mL	0.6502 mL