1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. LS-102

LS-102 

Cat. No.: HY-135844 Purity: 96.00%
Handling Instructions

LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.

For research use only. We do not sell to patients.

LS-102 Chemical Structure

LS-102 Chemical Structure

CAS No. : 1456891-34-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment[1][2].

In Vitro

LS-102 inhibits proliferation of RSCs with an IC50 of 5.4 µM[1].
LS-102 suppresses proliferation of rheumatoid synovial cells (RSCs) in a Syvn1-dependent manner. LS-102 suppresses polyubiquitination of target proteins of Syvn1, including nuclear factor erythroid 2-related factor 2 (NRF2), V247M α-sarcoglycan mutant, and PGC-1β. LS-102 inhibits E3 ligase activity of Synoviolin (Syvn1)[2].

Cell Viability Assay[1]

Cell Line: Rheumatoid synovial cells (RSCs)
Concentration: 20, 40, 60 μM
Incubation Time: 12 hours
Result: Inhibited proliferation of RSCs with an IC50 of 5.4 µM.
In Vivo

LS-102 (1.3-4 mg/kg; i.p.; daily for 4 weeks) reduces clinical severity scores in a CIA model[1].

Animal Model: 7-week-old DBA/1 male mice (CIA model)[1]
Dosage: 1.3, 4.0 mg/kg
Administration: I.p.; daily for 4 weeks
Result: Reduced the clinical severity scores.
Molecular Weight

452.60

Formula

C₂₄H₃₆N₈O

CAS No.

1456891-34-1

SMILES

CCNCCN(CC)C1=NC(NC2=CC=C3N=COC3=C2)=NC(N[[email protected]](C4CCCCC4)C)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LS-102LS102LS 102E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseproliferationrheumatoidsynovialcellsNRF2severityscoresCIAarthritisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LS-102
Cat. No.:
HY-135844
Quantity:
MCE Japan Authorized Agent: