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CP26 is a small molecule inhibitor of protein dislocation from the ER lumen to the cytosol. CP26 targets the Hrd1 complex, inhibits ERAD, and induces ER stress.

For research use only. We do not sell to patients.

CP26 Chemical Structure

CP26 Chemical Structure

CAS No. : 500285-30-3

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5 mg USD 480 In-stock
10 mg USD 820 In-stock
25 mg USD 1750 In-stock
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Based on 1 publication(s) in Google Scholar

CP26 Related Antibodies

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Description

CP26 is a small molecule inhibitor of protein dislocation from the ER lumen to the cytosol. CP26 targets the Hrd1 complex, inhibits ERAD, and induces ER stress[1].

In Vitro

CP26 exhibits a significant inhibitory activity against both DENV and ZIKV, providing substantial protection to the host cells against virus-induced cell death[1].
CP26 inhibits the ubiquitination and degradation of misfolded ER proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP26 Related Antibodies
Molecular Weight

306.01

Formula

C13H8Cl4
CAS No.
Appearance

Solid

Color

Pale purple to purple

SMILES

ClC(C(Cl)=C/1Cl)=C(Cl)C1=C\C2=CC=C(C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (81.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2679 mL 16.3393 mL 32.6787 mL
5 mM 0.6536 mL 3.2679 mL 6.5357 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2679 mL 16.3393 mL 32.6787 mL 81.6967 mL
5 mM 0.6536 mL 3.2679 mL 6.5357 mL 16.3393 mL
10 mM 0.3268 mL 1.6339 mL 3.2679 mL 8.1697 mL
15 mM 0.2179 mL 1.0893 mL 2.1786 mL 5.4464 mL
20 mM 0.1634 mL 0.8170 mL 1.6339 mL 4.0848 mL
25 mM 0.1307 mL 0.6536 mL 1.3071 mL 3.2679 mL
30 mM 0.1089 mL 0.5446 mL 1.0893 mL 2.7232 mL
40 mM 0.0817 mL 0.4085 mL 0.8170 mL 2.0424 mL
50 mM 0.0654 mL 0.3268 mL 0.6536 mL 1.6339 mL
60 mM 0.0545 mL 0.2723 mL 0.5446 mL 1.3616 mL
80 mM 0.0408 mL 0.2042 mL 0.4085 mL 1.0212 mL
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CP26 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP26500285-30-3CP 26CP-26OthersER lumenHrd1ERADER stressDENVZIKVInhibitorinhibitorinhibit

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