1456891-34-1
1456891-34-1
Chemical Structure
LS-102
- CAS No.: 1456891-34-1
- Formula:C24H36N8O
- Molecular Weight:452.60
IUPAC Name: (S)-N2-(benzo[d]oxazol-6-yl)-N4-(1-cyclohexylethyl)-N6-ethyl-N6-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine
InChIKey: DEDHMXBDEJSZFE-KRWDZBQOSA-N
SMILES: CCNCCN(CC)C1=NC(NC2=CC=C3N=COC3=C2)=NC(N[C@H](C4CCCCC4)C)=N1
Biological Activity: LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment[1][2].
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LS-102 | 97.89% | LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.48
HY-181884TLR9-IN-3 -
Similarity Score 0.46
HY-167877PS-166276 -
Similarity Score 0.46
HY-15723ANSC 23766 trihydrochloride -
Similarity Score 0.46
HY-15723RNSC 23766 (Standard) -
Similarity Score 0.46
HY-15858AP-III-a4 -
Similarity Score 0.46
HY-179226AP-7-168 -
Similarity Score 0.46
HY-15858AAP-III-a4 hydrochloride -
Similarity Score 0.45
HY-179133HDB-1 -
Similarity Score 0.45
HY-103438BIBU1361 -
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References
- [1]. Yagishita N, et al. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoidarthritis. Int J Mol Med. 2012 Dec;30(6):1281-6. [Content Brief]
- [2]. Fujita H, et al. Identification of the inhibitory activity of walnut extract on the E3 ligase Syvn1. Mol Med Rep. 2018 Dec;18(6):5701-5708. [Content Brief]
