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Cat. No.: HY-167877

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PS-166276

PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC₅₀ of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay.

For research use only. We do not sell to patients.

CAS No.: 348089-57-6
Formula: C₂₀H₃₀N₈O
Molecular Weight:398.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PS-166276 Chemical Structure

CAS No.: 348089-57-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC₅₀ of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay^[1].

All p38 MAPK Isoforms :

In Vivo

PS166276 (30 mg/kg, s.c., mice) inhibits LPS-induced TNFα production in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 348089-57-6
Molecular Weight 398.51
Formula C₂₀H₃₀N₈O
SMILES

CC(C)CN(C)C1=NC(N[C@@H]2CCNC2)=NC(NC3=CC(C(N)=O)=CC=C3C)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsung H Lin, et al. Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):495-502. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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