SLC1A1 - solute carrier family 1 member 1 Gene

Also Known as DCBXA; EAAC1; EAAT3; SCZD18; hEAAC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6505

About SLC1A1

Cytogenetic location: 9p24.2 Genomic coordinates (GRCh38): 9:4,490,468-4,587,469 (from NCBI)

This gene has 3 transcripts (splice variants), 251 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in small intestine (RPKM 11.7), kidney (RPKM 8.4) and 12 other tissues.

Summary

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

SLC1A1 Products (1)

mRNA	Protein	Name
NM_004170.6	NP_004161.4	excitatory amino acid transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D-aspartate transmembrane transporter activity	IDA IDA: Inferred from direct assay	7914198	GOA
enables L-aspartate transmembrane transporter activity	IDA IDA: Inferred from direct assay	7914198	GOA
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	7521911	GOA
enables chloride transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	8857541	GOA
enables cysteine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21123949	GOA
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	8857541	GOA
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	8857541	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in D-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in D-aspartate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	8857541	GOA
involved in D-aspartate transmembrane transport	IDA IDA: Inferred from direct assay	7914198	GOA
involved in L-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-aspartate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	8857541	GOA
involved in L-aspartate transmembrane transport	IDA IDA: Inferred from direct assay	7914198	GOA
involved in L-glutamate import	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	26690923	GOA
involved in L-glutamate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	8857541	GOA
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	7914198	GOA
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	12562531	GOA
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	8857541	GOA
involved in cysteine transport	IDA IDA: Inferred from direct assay	21123949	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21123949	GOA
located in membrane	IDA IDA: Inferred from direct assay	7914198	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	7914198	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21123949	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	8857541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC1A1 Protein Structure

SDF

0
100
200
300
400
500
524 a.a.

Protein Preferred Names	Protein Names
excitatory amino acid transporter 3	excitatory amino acid carrier 1

SLC1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC1A1	P43005	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	31515488
Intra	SLC1A1	P43005	SYNPR	Homo sapiens	Q8TBG9	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	SYNPR	Homo sapiens	Q8TBG9	Validated Y2H	32296183
Intra	SLC1A1	P43005	SYNPR	Homo sapiens	Q8TBG9	Y2H Array	32296183
Intra	SLC1A1	P43005	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	SLC1A1	P43005	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	SLC1A1	P43005	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	SLC1A1	P43005	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	SLC1A1	P43005	SLC35A1	Homo sapiens	P78382	Validated Y2H	32296183
Intra	SLC1A1	P43005	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SLC1A1	P43005	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SLC1A1	P43005	PAGE1	Homo sapiens	O75459	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	PAGE1	Homo sapiens	O75459	Y2H Array	32296183
Intra	SLC1A1	P43005	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	SLC1A1	P43005	RNF5	Homo sapiens	Q99942	Validated Y2H	25416956
Intra	SLC1A1	P43005	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	SLC1A1	P43005	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SLC1A1	P43005	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SLC1A1	P43005	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC1A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82620	EAAT3 Antibody (YA2365)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dicarboxylic Aminoaciduria	Glutamate-Aspartate Transport Defect Dicarboxylicaminoaciduria DCBXA Renal Aminoacidurias
Schizophrenia 18	SCZD18 Schizophrenia 18 With Or Without An Affective Disorder Schizophrenia Susceptibility 18 Chromosome 7q36.3 Duplication Syndrome, 362-Kb Schizophrenia, Type 18
Hot Water Reflex Epilepsy
Aminoaciduria
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Hemiplegia	Infantile Hemiplegia Postnatal Infantile Hemiplegia Hemiplegia, Infantile
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Episodic Ataxia, Type 6	Episodic Ataxia Type 6 EA6 Episodic Ataxia 6 Ea-6 Ataxia, Episodic, Type 6
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Glaucoma, Normal Tension	Low Tension Glaucoma Glaucoma, Normal Tension, Susceptibility To Normal Tension Glaucoma Ntg Glaucoma, Normal Pressure NPG Glaucoma, Normal Pressure, Susceptibility To Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Obsessive-Compulsive Personality Disorder	Anankastic Personality Disorder Obsessive-Compulsive Personality Compulsive Personality Disorder Ocpd Obsessional Personality Disorder
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Tic Disorder	Tics Behavioral Tic
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Retinal Degeneration	Degeneration Of Retina
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130125	SLC1A1/EAAT3-IN-1	Inhibitor	98.63%	Unkown
HY-RS13050	SLC1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21933	Slc1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC1A1	VGNC	VGNC:77409
Felis catus	SLC1A1	VGNC	VGNC:102980
Bos taurus	SLC1A1	VGNC	VGNC:34711
Rattus norvegicus	SLC1A1	RGD	RGD:3696
Canis familiaris	SLC1A1	VGNC	VGNC:46261
Mus musculus	SLC1A1	MGD	MGI:105083
Others	SLC1A1	NCBI