UBE2E2 - ubiquitin conjugating enzyme E2 E2 Gene

Also Known as UBCH8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7325

About UBE2E2

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:23,203,098-23,591,925 (from NCBI)

This gene has 7 transcripts (splice variants), 139 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 1.5), fat (RPKM 1.2) and 25 other tissues.

Summary

Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBE2E2 Products (5)

mRNA Protein Name
NM_001370225.1 NP_001357154.1 ubiquitin-conjugating enzyme E2 E2 isoform 1
NM_001370226.1 NP_001357155.1 ubiquitin-conjugating enzyme E2 E2 isoform 2
NM_001370227.1 NP_001357156.1 ubiquitin-conjugating enzyme E2 E2 isoform 3
NM_001370228.1 NP_001357157.1 ubiquitin-conjugating enzyme E2 E2 isoform 3
NM_152653.4 NP_689866.1 ubiquitin-conjugating enzyme E2 E2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ISG15 transferase activity IDA
IDA: Inferred from direct assay
16428300 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17460044 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
9371400 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
21628527 GOA
involved in ISG15-protein conjugation IDA
IDA: Inferred from direct assay
16428300 GOA
acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
21628527 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2E2 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (59 - 195)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 E2

  • E2 ubiquitin-conjugating enzyme E2

UBE2E2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra
UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25416956
Intra
UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra
UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
UBE2E2 Q96LR5 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
UBE2E2 Q96LR5 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
UBE2E2 Q96LR5 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
33961781
Intra
UBE2E2 Q96LR5 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
28514442
Intra
UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 CHFR Homo sapiens Q96EP1-2
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 CHFR Homo sapiens Q96EP1-2
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 PGPEP1 Homo sapiens Q9NXJ5-2
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 PGPEP1 Homo sapiens Q9NXJ5-2
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 PGPEP1 Homo sapiens Q9NXJ5-2
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
33961781
Intra
UBE2E2 Q96LR5 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
28514442
Intra
UBE2E2 Q96LR5 RNF25 Homo sapiens Q96BH1
Y2H Array
19549727
Intra
UBE2E2 Q96LR5 RNF115 Homo sapiens Q9Y4L5
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 RNF115 Homo sapiens Q9Y4L5
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 RNF115 Homo sapiens Q9Y4L5
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 TRIM3 Homo sapiens O75382
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 TRIM3 Homo sapiens O75382
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 RNF125 Homo sapiens Q96EQ8
Y2H Array
19549727
Intra
UBE2E2 Q96LR5 RNF185 Homo sapiens Q96GF1
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 RNF185 Homo sapiens Q96GF1
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Array
31515488
Intra
UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Prey Pooling
25416956
Intra
UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Array
25416956
Intra
UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H
21516116
Intra
UBE2E2 Q96LR5 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
25416956
Intra
UBE2E2 Q96LR5 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H Array
19549727
Intra
UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H
19549727
Intra
UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 CUEDC1 Homo sapiens Q9NWM3
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 CUEDC1 Homo sapiens Q9NWM3
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 CUEDC1 Homo sapiens Q9NWM3
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
Intra
UBE2E2 Q96LR5 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 DAZAP2 Homo sapiens Q15038
Y2H Array
25416956
Intra
UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9
Y2H
21516116
Intra
UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9
Y2H Array
31515488
Intra
UBE2E2 Q96LR5 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra
UBE2E2 Q96LR5 DZIP3 Homo sapiens Q86Y13
Y2H Array
29892012
Intra
UBE2E2 Q96LR5 DZIP3 Homo sapiens Q86Y13
Y2H
21516116
Intra
UBE2E2 Q96LR5 DZIP3 Homo sapiens Q86Y13
Y2H Array
31515488
Intra
UBE2E2 Q96LR5 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra
UBE2E2 Q96LR5 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 38 With Basal Ganglia Calcification

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency

  • IMD38

  • Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive

  • Immunodeficiency 38

  • Isg15 Deficiency, Autosomal Recessive

  • Immunodeficiency 38, With Basal Ganglia Calcification

  • Autosomal Recessive Isg15 Deficiency

  • Msmd Due To Complete Isg15 Deficiency

  • Immunodeficiency, Type 38
Intracranial Arteriosclerosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS29455 UBE2E2 Pig Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15343 UBE2E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2E2 VGNC VGNC:78415
Rattus norvegicus UBE2E2 RGD RGD:1305644
Mus musculus UBE2E2 MGD MGI:2384997
Bos taurus UBE2E2 VGNC VGNC:107010
Others UBE2E2 NCBI