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TRIM39 - tripartite motif containing 39 Gene

Also Known as TFP; RNF23; TRIM39B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56658

About TRIM39

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,326,469-30,343,729 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 128 orthologues and 80 paralogues. Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TRIM39 Products (5)

mRNA	Protein	Name
NM_001369521.2	NP_001356450.1	E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_001369522.1	NP_001356451.1	E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_001369523.1	NP_001356452.1	E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_021253.4	NP_067076.2	E3 ubiquitin-protein ligase TRIM39 isoform 1
NM_172016.2	NP_742013.1	E3 ubiquitin-protein ligase TRIM39 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	23213251	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	26363554	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23213251	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19100260	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19100260	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23213251	GOA
involved in regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	23213251	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	19100260	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19100260	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23213251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM39 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM39	RING-type E3 ubiquitin transferase TRIM39

TRIM39 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM39	Q9HCM9	SMCO3	Homo sapiens	A2RU48	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	SMCO3	Homo sapiens	A2RU48	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	SMCO3	Homo sapiens	A2RU48	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	DC-UbP	Homo sapiens	B2R886	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	DC-UbP	Homo sapiens	B2R886	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	DC-UbP	Homo sapiens	B2R886	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	EPHB6	Homo sapiens	O15197-2	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	EPHB6	Homo sapiens	O15197-2	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	EIF4A2	Homo sapiens	Q14240-2	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	EIF4A2	Homo sapiens	Q14240-2	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	DIP2A	Homo sapiens	Q14689-6	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	DIP2A	Homo sapiens	Q14689-6	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	RECK	Homo sapiens	Q6P9E2	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	WDFY3	Homo sapiens	Q8IZQ1-2	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	LXN	Homo sapiens	Q9BS40	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	LXN	Homo sapiens	Q9BS40	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	UBXN1	Homo sapiens	Q04323	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	UBXN6	Homo sapiens	Q9BZV1	Y2H Array	31515488
Intra	TRIM39	Q9HCM9	UBXN6	Homo sapiens	Q9BZV1	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	UBXN6	Homo sapiens	Q9BZV1	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	UBXN6	Homo sapiens	Q9BZV1	Y2H Array	29892012
Intra	TRIM39	Q9HCM9	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	19549727
Intra	TRIM39	Q9HCM9	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	UBE2E2	Homo sapiens	Q96LR5	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	ZNF26	Homo sapiens	P17031	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	ZNF26	Homo sapiens	P17031	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	ZNF26	Homo sapiens	P17031	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	UBE2D3	Homo sapiens	P61077	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	UBE2E3	Homo sapiens	Q969T4	Y2H Array	31515488
Intra	TRIM39	Q9HCM9	UBE2E3	Homo sapiens	Q969T4	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	UBE2E3	Homo sapiens	Q969T4	Y2H Array	19549727
Intra	TRIM39	Q9HCM9	UBE2E3	Homo sapiens	Q969T4	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	PSMA6	Homo sapiens	P60900	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	PSMA6	Homo sapiens	P60900	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	PSMA6	Homo sapiens	P60900	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	MED18	Homo sapiens	Q9BUE0	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	MED18	Homo sapiens	Q9BUE0	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	UBE2K	Homo sapiens	P61086	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	EIF4A2	Homo sapiens	Q14240	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	EIF4A2	Homo sapiens	Q14240	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	TRIM17	Homo sapiens	Q9Y577	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	TRIM17	Homo sapiens	Q9Y577	Y2H Array	29892012
Intra	TRIM39	Q9HCM9	TRIM39	Homo sapiens	Q9HCM9	Pull Down	16189514
Intra	TRIM39	Q9HCM9	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	22493164
Intra	TRIM39	Q9HCM9	TRIM17	Homo sapiens	Q9Y577	Y2H Array	31515488
Intra	TRIM39	Q9HCM9	UBE2D1	Homo sapiens	P51668	Y2H	21516116
Intra	TRIM39	Q9HCM9	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	TRIM39	Homo sapiens	Q9HCM9	Y2H	21516116
Intra	TRIM39	Q9HCM9	TRIM17	Homo sapiens	Q9Y577	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	UBE2D1	Homo sapiens	P51668	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	TRIM39	Homo sapiens	Q9HCM9	Y2H Pooling	16189514
Intra	TRIM39	Q9HCM9	TRIM39	Homo sapiens	Q9HCM9	Anti Tag CoIP	22493164
Intra	TRIM39	Q9HCM9	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	TRIM39	Q9HCM9	TRIM17	Homo sapiens	Q9Y577	Y2H Array	22493164
Intra	TRIM39	Q9HCM9	UBE2D1	Homo sapiens	P51668	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	DCUN1D1	Homo sapiens	Q96GG9	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	DCUN1D1	Homo sapiens	Q96GG9	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	POLI	Homo sapiens	Q9UNA4	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	PRPF3	Homo sapiens	O43395	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	PRPF3	Homo sapiens	O43395	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	PRPF3	Homo sapiens	O43395	Y2H	21516116
Intra	TRIM39	Q9HCM9	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	UBTD1	Homo sapiens	Q9HAC8	Y2H Pooling	16189514
Intra	TRIM39	Q9HCM9	UBTD1	Homo sapiens	Q9HAC8	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	UBAC1	Homo sapiens	Q9BSL1	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	UBAC1	Homo sapiens	Q9BSL1	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	PSMD9	Homo sapiens	O00233	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	PSMD9	Homo sapiens	O00233	Y2H Array	25416956
Intra	TRIM39	Q9HCM9	PSMD9	Homo sapiens	O00233	Y2H	21516116
Intra	TRIM39	Q9HCM9	TRIM21	Homo sapiens	P19474	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	TRIM21	Homo sapiens	P19474	Y2H Array	22493164
Intra	TRIM39	Q9HCM9	TTC32	Homo sapiens	Q5I0X7	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	a8k2r3_human	Homo sapiens	A8K2R3	Validated Y2H	25416956
Intra	TRIM39	Q9HCM9	a8k2r3_human	Homo sapiens	A8K2R3	Y2H Prey Pooling	25416956
Intra	TRIM39	Q9HCM9	a8k2r3_human	Homo sapiens	A8K2R3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome	Glomerulonephritis With Sparse Hair And Telangiectases Telangiectatic Membranoproliferative Glomerulonephritis HLTRS Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hlt-Renal Defect Syndrome Glomerulonephritis Sparse Hair Telangiectases
Shoulder Impingement Syndrome	Impingement Syndrome Of Shoulder Region Subacromial Impingement

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15043	TRIM39 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM39	MGD	MGI:1890659
Rattus norvegicus	TRIM39	RGD	RGD:1303115
Others	TRIM39	NCBI