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UBXN6 - UBX domain protein 6 Gene

Also Known as UBXD1; UBXDC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80700

About UBXN6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,445,006-4,457,879 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.0), kidney (RPKM 36.6) and 25 other tissues.

Summary

Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Is extrinsic component of membrane. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN6 Products (2)

mRNA	Protein	Name
NM_001171091.2	NP_001164562.1	UBX domain-containing protein 6 isoform 2
NM_025241.3	NP_079517.1	UBX domain-containing protein 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18656546	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	19275885	GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21822278	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	27753622	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27753622	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19275885	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	21822278	GOA
located in endosome	IDA IDA: Inferred from direct assay	26475856	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	21822278	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	21822278	GOA
located in membrane	IDA IDA: Inferred from direct assay	19275885	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21822278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN6 Protein Structure

PUB

UBX

0
100
200
300
400
441 a.a.

Protein Preferred Names	Protein Names
UBX domain-containing protein 6	CTB-50L17.16

UBXN6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Validated Y2H	25416956
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Y2H Array	25416956
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Y2H Prey Pooling	25416956
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Anti Tag CoIP	33961781
Intra	UBXN6	Q9BZV1	SVIP	Homo sapiens	Q8NHG7	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	SVIP	Homo sapiens	Q8NHG7	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	SUSD6	Homo sapiens	Q92537	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	SUSD6	Homo sapiens	Q92537	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Bait CoIP	18656546
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	BRET	29997244
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Pull Down	18656546
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Lumier	29997244
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313
Intra	UBXN6	Q9BZV1	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1	Ibmpfd1 Msp1 Multisystem Proteinopathy 1
Multisystem Proteinopathy
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15398	UBXN6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBXN6	VGNC	VGNC:36628
Macaca mulatta	UBXN6	VGNC	VGNC:78971
Canis familiaris	UBXN6	VGNC	VGNC:48101
Rattus norvegicus	UBXN6	RGD	RGD:1590866
Felis catus	UBXN6	VGNC	VGNC:80752
Mus musculus	UBXN6	MGD	MGI:1913780
Others	UBXN6	NCBI