DAZAP2 - DAZ associated protein 2 Gene

Homo sapiens

Also known as PRTB

Gene ID: 9802 | Gene type: protein coding

About DAZAP2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,238,826-51,246,717 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in bone marrow (RPKM 168.5), thyroid (RPKM 98.1) and 25 other tissues.

Summary

This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

DAZAP2 Products(6)

mRNA	Protein	Name
NM_001136264.2	NP_001129736.1	DAZ-associated protein 2 isoform b
NM_001136266.2	NP_001129738.1	DAZ-associated protein 2 isoform c
NM_001136267.2	NP_001129739.1	DAZ-associated protein 2 isoform d
NM_001136268.2	NP_001129740.1	DAZ-associated protein 2 isoform e
NM_001136269.2	NP_001129741.1	DAZ-associated protein 2 isoform f
NM_014764.4	NP_055579.1	DAZ-associated protein 2 isoform a

DAZAP2 Protein Structure

DAZAP2

0
100
168 a.a.

Protein Preferred Names

Protein Names

DAZ-associated protein 2

deleted in azoospermia associated protein 2

Related Diseases

Diseases

Alias

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03541	DAZAP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAZAP2	VGNC	VGNC:27886
Mus musculus	DAZAP2	MGD	MGI:1344344
Canis familiaris	DAZAP2	VGNC	VGNC:39779
Macaca mulatta	DAZAP2	VGNC	VGNC:99922
Rattus norvegicus	DAZAP2	RGD	RGD:1307407
Felis catus	DAZAP2	VGNC	VGNC:83864

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