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PDIK1L - PDLIM1 interacting kinase 1 like Gene

Also Known as CLIK1L; STK35L2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 149420

About PDIK1L

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,111,162-26,125,555 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 7.2), bone marrow (RPKM 4.5) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PDIK1L Products (3)

mRNA	Protein	Name
NM_001243532.2	NP_001230461.1	serine/threonine-protein kinase PDIK1L
NM_001243533.2	NP_001230462.1	serine/threonine-protein kinase PDIK1L
NM_152835.5	NP_690048.1	serine/threonine-protein kinase PDIK1L

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIK1L Protein Structure

Pkinase

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PDIK1L	casein kinase

PDIK1L Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDIK1L	Q8N165	CTDSPL2	Homo sapiens	Q05D32	Anti Tag CoIP	33961781
Intra	PDIK1L	Q8N165	CTDSPL2	Homo sapiens	Q05D32	Y2H Array	32296183
Intra	PDIK1L	Q8N165	CTDSPL2	Homo sapiens	Q05D32	Anti Tag CoIP	28514442
Intra	PDIK1L	Q8N165	CTDSPL2	Homo sapiens	Q05D32	Y2H Prey Pooling	32296183
Intra	PDIK1L	Q8N165	CTDSPL2	Homo sapiens	Q05D32	Pull Down	32707033
Intra	PDIK1L	Q8N165	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	PDIK1L	Q8N165	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	PDIK1L	Q8N165	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	PDIK1L	Q8N165	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	28514442
Intra	PDIK1L	Q8N165	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	PDIK1L	Q8N165	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	PDIK1L	Q8N165	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	PDIK1L	Q8N165	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	PDIK1L	Q8N165	C1orf174	Homo sapiens	Q8IYL3	Y2H Array	32296183
Intra	PDIK1L	Q8N165	C1orf174	Homo sapiens	Q8IYL3	Anti Tag CoIP	28514442
Intra	PDIK1L	Q8N165	C1orf174	Homo sapiens	Q8IYL3	Pull Down	32707033
Intra	PDIK1L	Q8N165	C1orf174	Homo sapiens	Q8IYL3	Y2H Prey Pooling	32296183
Intra	PDIK1L	Q8N165	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	PDIK1L	Q8N165	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Axenfeld-Rieger Syndrome, Type 1	Axenfeld-Rieger Syndrome Type 1 RIEG1 Rieg Rgs Rieger Syndrome Type 1 Rieger Syndrome, Type 1 Axenfeld-Rieger Syndrome 1 Iridogoniodysgenesis With Somatic Anomalies
Acromesomelic Dysplasia 2c	Acromesomelic Dysplasia, Hunter-Thompson Type Acromesomelic Dysplasia 2c, Hunter-Thompson Type AMD2C Acromesomelic Dwarfism Amdh Acromesomelic Dwarfism Acromesomelic Dysplasia-2c Acromesomelic Dysplasia Hunter Thompson Type Acromesomelic Chondrodysplasia, Hunter-Thompson Type Amdh Dysplasia, Acromesomelic, Type 2c, Hunter-Thompson Acromesomelic Dysplasia Hunter-Thompson Type
Nail Disorder, Nonsyndromic Congenital, 4	Anonychia Congenita Anonychia Hyponychia Congenita NDNC4 Anonychia/Hyponychia Congenita Nonsyndromic Congenital Nail Disorder 4 Isolated Congenital Anonychia Anonychia Congenita Totalis Anonychia Totalis Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4 Congenital Anonychia Nonsyndromic Congenital Nail Disorder, 4 Absent Nails Aplastic Nails Congenital Absence Of Nails Isolated Anonychia Nail Disorder, Non-Syndromic Congenital, 4 Nail Disorder, Nonsyndromic, Congenital, Type 4
Nonsyndromic Congenital Nail Disorder	Nail Disorder, Nonsyndromic Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-RS10272	PDIK1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDIK1L	VGNC	VGNC:75830
Bos taurus	PDIK1L	VGNC	VGNC:32701
Mus musculus	PDIK1L	MGD	MGI:2385213
Canis familiaris	PDIK1L	VGNC	VGNC:44379
Rattus norvegicus	PDIK1L	RGD	RGD:1307476
Felis catus	PDIK1L	VGNC	VGNC:64087
Others	PDIK1L	NCBI