KLHL42 - kelch like family member 42 Gene
Also Known as Ctb9; KLHDC5
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 57542
Summary
Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in brain (RPKM 7.6), endometrium (RPKM 5.0) and 25 other tissues.
KLHL42 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_020782.2 | NP_065833.1 | kelch-like protein 42 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| contributes to ubiquitin-protein transferase activity |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in proteasome-mediated ubiquitin-dependent protein catabolic process |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
| involved in protein polyubiquitination |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
| involved in regulation of microtubule-based process |
IMP
IMP: Inferred from mutant phenotype
|
19261606 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of Cul3-RING ubiquitin ligase complex |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
KLHL42 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN1 | Homo sapiens | Q9UMX0-2 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | STXBP4 | Homo sapiens | Q08AL9 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | STXBP4 | Homo sapiens | Q08AL9 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | STXBP4 | Homo sapiens | Q08AL9 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | POMC | Homo sapiens | P01189 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | POMC | Homo sapiens | P01189 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | KRTAP19-4 | Homo sapiens | Q3LI73 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | KRTAP19-4 | Homo sapiens | Q3LI73 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | ANKRD33 | Homo sapiens | Q7Z3H0-1 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | ANKRD33 | Homo sapiens | Q7Z3H0-1 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CDCA4 | Homo sapiens | Q9BXL8 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CDCA4 | Homo sapiens | Q9BXL8 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | VPS52 | Homo sapiens | Q8N1B4 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | VPS52 | Homo sapiens | Q8N1B4 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | STAM2 | Homo sapiens | O75886 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | STAM2 | Homo sapiens | O75886 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | STAM2 | Homo sapiens | O75886 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | STAM2 | Homo sapiens | O75886 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | MYOG | Homo sapiens | P15173 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | MYOG | Homo sapiens | P15173 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | P4HB | Homo sapiens | P07237 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | P4HB | Homo sapiens | P07237 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CT55 | Homo sapiens | Q8WUE5 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CT55 | Homo sapiens | Q8WUE5 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CKMT2 | Homo sapiens | P17540 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CKMT2 | Homo sapiens | P17540 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | DDI1 | Homo sapiens | Q8WTU0 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | DDI1 | Homo sapiens | Q8WTU0 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | DDI1 | Homo sapiens | Q8WTU0 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | DDI1 | Homo sapiens | Q8WTU0 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | SERTAD1 | Homo sapiens | Q9UHV2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | SERTAD1 | Homo sapiens | Q9UHV2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | SERTAD1 | Homo sapiens | Q9UHV2 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | SERTAD3 | Homo sapiens | Q9UJW9 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | SERTAD3 | Homo sapiens | Q9UJW9 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | SERTAD3 | Homo sapiens | Q9UJW9 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | FAM168A | Homo sapiens | Q92567 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | FAM168A | Homo sapiens | Q92567 | 25416956 | |
|
Intra
|
KLHL42 | Q9P2K6 | ADD1 | Homo sapiens | Q96D30 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | ADD1 | Homo sapiens | Q96D30 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | TTC23 | Homo sapiens | Q5W5X9-3 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | TTC23 | Homo sapiens | Q5W5X9-3 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
KLHL42 | Q9P2K6 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(2)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-162318 | MYC degrader 1 | 99.61% | Unkown | |
| HY-162318A | MYC degrader 1 TFA | Degrader | 99.36% | Unkown |
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