MYC degrader 1

Cat. No.: HY-162318: FAQs
Data Sheet Handling Instructions

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A80.2HCl is a MYC degrader that restores pRB1 protein activity and reduces MYC-dependent CDK4/6 resistance. A80.2HCl has antitumor activity.

For research use only. We do not sell to patients.

MYC degrader 1 Chemical Structure

CAS No. : 2946670-96-6

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Purity & Documentation
References
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Description

A80.2HCl is a MYC degrader that restores pRB1 protein activity and reduces MYC-dependent CDK4/6 resistance. A80.2HCl has antitumor activity^[1].

Molecular Weight

626.07

Formula

C₃₂H₃₁ClF₃N₅O₃

CAS No.

2946670-96-6

SMILES

ClC1=CC(C2=CC(C(F)(F)F)=C(N3CCC(CNCC4=CC(CN(C5C(NC(CC5)=O)=O)C6=O)=C6C=C4)CC3)N=C2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (159.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5973 mL	7.9863 mL	15.9727 mL
5 mM	0.3195 mL	1.5973 mL	3.1945 mL
10 mM	0.1597 mL	0.7986 mL	1.5973 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ma J, et al. MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nat Commun. 2024 Feb 29;15(1):1871. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5973 mL	7.9863 mL	15.9727 mL	39.9316 mL
	5 mM	0.3195 mL	1.5973 mL	3.1945 mL	7.9863 mL
	10 mM	0.1597 mL	0.7986 mL	1.5973 mL	3.9932 mL
	15 mM	0.1065 mL	0.5324 mL	1.0648 mL	2.6621 mL
	20 mM	0.0799 mL	0.3993 mL	0.7986 mL	1.9966 mL
	25 mM	0.0639 mL	0.3195 mL	0.6389 mL	1.5973 mL
	30 mM	0.0532 mL	0.2662 mL	0.5324 mL	1.3311 mL
	40 mM	0.0399 mL	0.1997 mL	0.3993 mL	0.9983 mL
	50 mM	0.0319 mL	0.1597 mL	0.3195 mL	0.7986 mL
	60 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.6655 mL
	80 mM	0.0200 mL	0.0998 mL	0.1997 mL	0.4991 mL
	100 mM	0.0160 mL	0.0799 mL	0.1597 mL	0.3993 mL

MYC degrader 1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MYC degrader 12946670-96-6MYC degrader1MYC degrader-1c-MycMycMYCDegraderpRB1AntitumorInhibitorinhibitorinhibit

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