MYOG - myogenin Gene
Also Known as MYF4; myf-4; bHLHc3
Species: Homo sapiens
About MYOG
This gene has 1 transcript (splice variant), 199 orthologues and 3 paralogues. Biased expression in prostate (RPKM 2.6) and esophagus (RPKM 0.9).
Summary
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
MYOG Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002479.6 | NP_002470.2 | myogenin |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA
IDA: Inferred from direct assay
|
11076940 | GOA |
| enables RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
11076940 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
11076940 | GOA |
| enables sequence-specific double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
28473536 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
11076940 | GOA |
MYOG Protein Structure
Basic: Myogenic Basic domain (1 - 81)
HLH: Helix-loop-helix DNA-binding domain (82 - 133)
- 0
- 100
- 200
- 224 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myogenin |
|
MYOG Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MYOG | P15173 | BFSP2 | Homo sapiens | Q13515 | 32296183 | |
|
Intra
|
MYOG | P15173 | CCDC28A | Homo sapiens | Q7Z6N9 | 32296183 | |
|
Intra
|
MYOG | P15173 | CCDC28A | Homo sapiens | Q7Z6N9 | 25416956 | |
|
Intra
|
MYOG | P15173 | ODAD4 | Homo sapiens | Q96NG3 | 25416956 | |
|
Intra
|
MYOG | P15173 | PACRGL | Homo sapiens | Q8N7B6-2 | 32296183 | |
|
Intra
|
MYOG | P15173 | ABI2 | Homo sapiens | Q9NYB9-2 | 32296183 | |
|
Intra
|
MYOG | P15173 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
MYOG | P15173 | LMO3 | Homo sapiens | Q8TAP4-4 | 32296183 | |
|
Intra
|
MYOG | P15173 | NEK6 | Homo sapiens | Q9HC98-4 | 32296183 | |
|
Intra
|
MYOG | P15173 | CTNNA3 | Homo sapiens | Q9UI47-2 | 32296183 | |
|
Intra
|
MYOG | P15173 | FIGLA | Homo sapiens | Q6QHK4 | 32296183 | |
|
Intra
|
MYOG | P15173 | ID1 | Homo sapiens | P41134 | 32296183 | |
|
Intra
|
MYOG | P15173 | ID1 | Homo sapiens | P41134 | 32296183 | |
|
Intra
|
MYOG | P15173 | IKBIP | Homo sapiens | Q70UQ0-4 | 32296183 | |
|
Intra
|
MYOG | P15173 | IKBIP | Homo sapiens | Q70UQ0-4 | 31515488 | |
|
Intra
|
MYOG | P15173 | IL16 | Homo sapiens | Q14005-2 | 32296183 | |
|
Intra
|
MYOG | P15173 | FAM110A | Homo sapiens | Q9BQ89 | 32296183 | |
|
Intra
|
MYOG | P15173 | BBS4 | Homo sapiens | Q96RK4 | 25416956 | |
|
Intra
|
MYOG | P15173 | BBS4 | Homo sapiens | Q96RK4 | 25416956 | |
|
Intra
|
MYOG | P15173 | IKBIP | Homo sapiens | Q70UQ0 | 25416956 | |
|
Intra
|
MYOG | P15173 | IKBIP | Homo sapiens | Q70UQ0 | 25416956 | |
|
Intra
|
MYOG | P15173 | TSSK3 | Homo sapiens | Q96PN8 | 32296183 | |
|
Intra
|
MYOG | P15173 | PACRGL | Homo sapiens | Q8N7B6 | 25416956 | |
|
Intra
|
MYOG | P15173 | ZCCHC14 | Homo sapiens | Q8WYQ9 | 32296183 | |
|
Intra
|
MYOG | P15173 | POLR2J | Homo sapiens | P52435 | 32296183 | |
|
Intra
|
MYOG | P15173 | FAM90A1 | Homo sapiens | Q86YD7 | 32296183 | |
|
Intra
|
MYOG | P15173 | TXNDC9 | Homo sapiens | O14530 | 25416956 | |
|
Intra
|
MYOG | P15173 | TXNDC9 | Homo sapiens | O14530 | 25416956 | |
|
Intra
|
MYOG | P15173 | FTL | Homo sapiens | P02792 | 25416956 | |
|
Intra
|
MYOG | P15173 | FTL | Homo sapiens | P02792 | 25416956 | |
|
Intra
|
MYOG | P15173 | TCF12 | Homo sapiens | Q99081 | 33961781 | |
|
Intra
|
MYOG | P15173 | CLUAP1 | Homo sapiens | Q96AJ1 | 25416956 | |
|
Intra
|
MYOG | P15173 | CLUAP1 | Homo sapiens | Q96AJ1 | 25416956 | |
|
Intra
|
MYOG | P15173 | CLUAP1 | Homo sapiens | Q96AJ1 | 32296183 | |
|
Intra
|
MYOG | P15173 | KLHL42 | Homo sapiens | Q9P2K6 | 32296183 | |
|
Intra
|
MYOG | P15173 | USHBP1 | Homo sapiens | Q8N6Y0 | 32296183 | |
|
Intra
|
MYOG | P15173 | CFAP53 | Homo sapiens | Q96M91 | 32296183 | |
|
Intra
|
MYOG | P15173 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
MYOG | P15173 | GEM | Homo sapiens | P55040 | 32296183 | |
|
Intra
|
MYOG | P15173 | MLH1 | Homo sapiens | P40692 | 25416956 | |
|
Intra
|
MYOG | P15173 | MLH1 | Homo sapiens | P40692 | 29892012 | |
|
Intra
|
MYOG | P15173 | MLH1 | Homo sapiens | P40692 | 31515488 | |
|
Intra
|
MYOG | P15173 | MLH1 | Homo sapiens | P40692 | 32296183 | |
|
Intra
|
MYOG | P15173 | CCDC120 | Homo sapiens | Q96HB5 | 32296183 | |
|
Intra
|
MYOG | P15173 | BHLHA15 | Homo sapiens | Q7RTS1 | 32296183 |
MYOG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81189 | Myogenin Antibody | WB, IHC-P, FC | Human, Mouse, Rat |
| HY-P81189A | Myogenin Antibody(PBS only) | WB, IHC-P, FC | Human, Mouse, Rat |
| HY-P85999 | Myogenin Antibody (YA5691) | IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Embryonal Rhabdomyosarcoma |
|
|
| Leiomyosarcoma |
|
|
| Muscle Cancer |
|
|
| Alveolar Soft Part Sarcoma |
|
|
| Botryoid Rhabdomyosarcoma |
|
|
| Rhabdomyosarcoma 2 |
|
|
| Mesenchymal Chondrosarcoma |
|
|
| Malignant Fibrous Histiocytoma |
|
|
| Skeletal Muscle Cancer |
|
|
| Ectomesenchymoma |
|
|
| Central Nervous System Mesenchymal Non-Meningothelial Tumor |
|
|
| Inflammatory Leiomyosarcoma |
|
|
| Pleomorphic Rhabdomyosarcoma |
|
|
| Prostate Embryonal Rhabdomyosarcoma |
|
|
| Breast Rhabdomyosarcoma |
|
|
| Oral Rhabdomyosarcoma |
|
|
| Cervical Polyp |
|
|
| Cervical Adenosarcoma |
|
|
| Bile Duct Rhabdomyosarcoma |
|
|
| Rhabdomyosarcoma |
|
|
| Orbit Rhabdomyosarcoma |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Skeletal Muscle Neoplasm |
|
|
| Pseudosarcomatous Fibromatosis |
|
|
| Prostate Rhabdomyosarcoma |
|
|
| Parietal Lobe Neoplasm |
|
|
| Malignant Mesenchymoma |
|
|
| Conventional Leiomyosarcoma |
|
|
| Spindle Cell Rhabdomyosarcoma |
|
|
| Malignant Triton Tumor |
|
|
| Medullomyoblastoma |
|
|
| Prostate Sarcoma |
|
|
| Myocardium Cancer |
|
|
| Embryonal Carcinoma |
|
|
| Batten-Turner Congenital Myopathy |
|
|
| Vagina Leiomyosarcoma |
|
|
| Ovarian Mesodermal Adenosarcoma |
|
|
| Malignant Glandular Tumor Of Peripheral Nerve Sheath |
|
|
| Liposarcoma |
|
|
| Sarcoma |
|
|
| Pineal Region Teratoma |
|
|
| Desmoplastic Small Round Cell Tumor |
|
|
| Cervical Neuroblastoma |
|
|
| Bladder Sarcoma |
|
|
| Fallopian Tube Endometrioid Adenocarcinoma |
|
|
| Myotonic Dystrophy 1 |
|
|
| Myoblastoma |
|
|
| Ewing Sarcoma |
|
|
| Muscular Disease |
|
|
| Scrotum Neoplasm |
|
|
| Progressive Relapsing Multiple Sclerosis |
|
|
| Adult Fibrosarcoma |
|
|
| Gallbladder Sarcoma |
|
|
| Blastoma |
|
|
| Cervical Carcinosarcoma |
|
|
| Heart Cancer |
|
|
| Monophasic Synovial Sarcoma |
|
|
| Myofibroma |
|
|
| Retinoblastoma |
|
|
| Extracranial Neuroblastoma |
|
|
| Heart Sarcoma |
|
|
| Extraosseous Ewing Sarcoma |
|
|
| Heart Lymphoma |
|
|
| Spindle Cell Sarcoma |
|
|
| Epithelioid Malignant Peripheral Nerve Sheath Tumor |
|
|
| Epithelioid Leiomyosarcoma |
|
|
| Facioscapulohumeral Muscular Dystrophy 1 |
|
|
| Kidney Cortex Disease |
|
|
| Clear Cell Basal Cell Carcinoma |
|
|
| Adult Malignant Schwannoma |
|
|
| Sarcomatoid Squamous Cell Skin Carcinoma |
|
|
| Synovium Cancer |
|
|
| Uterine Inversion |
|
|
| Breast Sarcoma |
|
|
| Gas Gangrene |
|
|
| Askin'S Tumor |
|
|
| Carey-Fineman-Ziter Syndrome 1 |
|
|
| Muscle Tissue Disease |
|
|
| Congenital Fibrosarcoma |
|
|
| Childhood Fibrosarcoma |
|
|
| Mesenchymal Cell Neoplasm |
|
|
| Liposarcoma Of Bone |
|
|
| Retroperitoneal Sarcoma |
|
|
| Medulloepithelioma |
|
|
| Muscular Dystrophy, Congenital, Lmna-Related |
|
|
| Extraosseous Osteosarcoma |
|
|
| Myxofibrosarcoma |
|
|
| Lung Sarcoma |
|
|
| Liver Sarcoma |
|
|
| Orbit Embryonal Rhabdomyosarcoma |
|
|
| Perivascular Tumor |
|
|
| Pleomorphic Liposarcoma |
|
|
| Pleuropulmonary Blastoma |
|
|
| Sarcomatosis |
|
|
| Conventional Osteosarcoma |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Mixed Cell Type Cancer |
|
|
| Vascular Cancer |
|
|
| Hobnail Hemangioma |
|
|
| Endobronchial Leiomyoma |
|
|
| Large Cell Carcinoma With Rhabdoid Phenotype |
|
|
| Infantile Myofibromatosis |
|
|
| Dedifferentiated Liposarcoma |
|
|
| Sarcoma, Synovial |
|
|
| Well-Differentiated Liposarcoma |
|
|
| Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant |
|
|
| Parameningeal Embryonal Rhabdomyosarcoma |
|
|
| Bone Osteosarcoma |
|
|
| Prostate Stromal Sarcoma |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Vagina Sarcoma |
|
|
| Endometrial Stromal Sarcoma |
|
|
| Partial Third-Nerve Palsy |
|
|
| Ullrich Congenital Muscular Dystrophy 1 |
|
|
| Limb-Girdle Muscular Dystrophy |
|
|
| Medulloblastoma |
|
|
| Atypical Teratoid Rhabdoid Tumor |
|
|
| Cardiomyopathy, Familial Hypertrophic, 1 |
|
|
| Wilms Tumor 1 |
|
|
| Neuromuscular Disease |
|
|
| Myopathy |
|
|
| Peripheral Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | MYOG | VGNC | VGNC:43580 |
| Rattus norvegicus | MYOG | RGD | RGD:620432 |
| Mus musculus | MYOG | MGD | MGI:97276 |
| Bos taurus | MYOG | VGNC | VGNC:31837 |
| Macaca mulatta | MYOG | VGNC | VGNC:100017 |
| Felis catus | MYOG | VGNC | VGNC:107899 |
| Others | MYOG | NCBI |