ODAD4 - outer dynein arm docking complex subunit 4 Gene

Also Known as TTC25

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 83538

Summary

This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

ODAD4 Products (1)

mRNA Protein Name
NM_001350319.2 NP_001337248.1 outer dynein arm-docking complex subunit 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium movement IDA
IDA: Inferred from direct assay
27486780 GOA
involved in epithelial cilium movement involved in determination of left/right asymmetry IMP
IMP: Inferred from mutant phenotype
27486780 GOA
involved in mucociliary clearance IMP
IMP: Inferred from mutant phenotype
27486780 GOA
involved in outer dynein arm assembly IDA
IDA: Inferred from direct assay
27486780 GOA
involved in protein localization to motile cilium IMP
IMP: Inferred from mutant phenotype
27486780 GOA
Cellular Component GO Annotation Evidence References Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
27486780 GOA
located in axoneme IDA
IDA: Inferred from direct assay
27486780 GOA
part of outer dynein arm docking complex IDA
IDA: Inferred from direct assay
27486780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

outer dynein arm-docking complex subunit 4

  • TPR repeat protein 25

  • tetratricopeptide repeat domain 25

  • tetratricopeptide repeat protein 25

ODAD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ODAD4 Q96NG3 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
ODAD4 Q96NG3 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
ODAD4 Q96NG3 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
25416956
Intra
ODAD4 Q96NG3 MYOG Homo sapiens P15173
Y2H Prey Pooling
25416956
Intra
ODAD4 Q96NG3 MYOG Homo sapiens P15173
Validated Y2H
25416956
Intra
ODAD4 Q96NG3 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
ODAD4 Q96NG3 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
ODAD4 Q96NG3 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra
ODAD4 Q96NG3 CCDC85B Homo sapiens Q15834
Y2H Array
25416956
Intra
ODAD4 Q96NG3 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
ODAD4 Q96NG3 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction