GEM - GTP binding protein overexpressed in skeletal muscle Gene

Homo sapiens

Also known as KIR

Gene ID: 2669 | Gene type: protein coding

About GEM

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,249,253-94,262,319 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 35 paralogues. Broad expression in gall bladder (RPKM 114.4), urinary bladder (RPKM 36.5) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GEM Products(2)

mRNA	Protein	Name
NM_005261.4	NP_005252.1	GTP-binding protein GEM
NM_181702.3	NP_859053.1	GTP-binding protein GEM

GEM Protein Structure

Ras

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

GTP-binding protein GEM

GTP-binding mitogen-induced T-cell protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149906	Trecovirsen	Inhibitor	98.83%	Unkown
HY-143411	GEM144		/	Unkown
HY-145314	TC113		/	Unkown
HY-145441	GEM–IB		/	Unkown
HY-146540	GEM-5		/	Unkown
HY-148827	GEM-231	Inhibitor	/	Unkown
HY-148827A	GEM-231 sodium	Inhibitor	/	Unkown
HY-149906A	FITC-Trecovirsen sodium	Inhibitor	/	Unkown
HY-154842	S-Gem		/	Unkown
HY-154843	C-Gem		/	Unkown
HY-RS05366	GEM Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GEM	MGD	MGI:99844
Bos taurus	GEM	VGNC	VGNC:29315
Rattus norvegicus	GEM	RGD	RGD:1307386
Canis familiaris	GEM	VGNC	VGNC:41172
Felis catus	GEM	VGNC	VGNC:62512
Susscrofa domestica	GEM	NCBI
Macaca mulatta	GEM	NCBI
Others	GEM	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.