2. Gene
  3. INSC - INSC spindle orientation adaptor protein Gene

INSC - INSC spindle orientation adaptor protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 387755 | Gene type: protein coding

About INSC

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,111,416-15,269,676 (from NCBI)

This gene has 8 transcripts (splice variants) and 198 orthologues. Low expression observed in reference dataset.

Summary

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

INSC Products(6)

mRNA Protein Name
NM_001031853.5 NP_001027024.3 protein inscuteable homolog isoform a
NM_001042536.3 NP_001036001.1 protein inscuteable homolog isoform b
NM_001278313.2 NP_001265242.1 protein inscuteable homolog isoform b
NM_001278314.2 NP_001265243.1 protein inscuteable homolog isoform c
NM_001278315.2 NP_001265244.1 protein inscuteable homolog isoform d
NM_001278316.2 NP_001265245.1 protein inscuteable homolog isoform e
Protein Preferred Names Protein Names

protein inscuteable homolog

inscuteable homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145758 FEN1-IN-SC13 Inhibitor 98.89% Unkown
HY-131236 EBNA1-IN-SC7 99.92% Unkown
HY-RS06836 INSC Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus INSC RGD RGD:1311379
Bos taurus INSC VGNC VGNC:30216
Macaca mulatta INSC VGNC VGNC:73693
Mus musculus INSC MGD MGI:1917942
Canis familiaris INSC VGNC VGNC:42038
Felis catus INSC VGNC VGNC:62932