INSC - INSC spindle orientation adaptor protein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387755

About INSC

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,111,416-15,269,676 (from NCBI)

This gene has 8 transcripts (splice variants) and 198 orthologues. Low expression observed in reference dataset.

Summary

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

INSC Products (6)

mRNA Protein Name
NM_001031853.5 NP_001027024.3 protein inscuteable homolog isoform a
NM_001042536.3 NP_001036001.1 protein inscuteable homolog isoform b
NM_001278313.2 NP_001265242.1 protein inscuteable homolog isoform b
NM_001278314.2 NP_001265243.1 protein inscuteable homolog isoform c
NM_001278315.2 NP_001265244.1 protein inscuteable homolog isoform d
NM_001278316.2 NP_001265245.1 protein inscuteable homolog isoform e

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16458856 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
22074847 GOA
enables protein-macromolecule adaptor activity IPI
IPI: Inferred from physical interaction
16458856 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
22074847 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with cell cortex IMP
IMP: Inferred from mutant phenotype
22074847 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
22074847 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
16458856 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
22074847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein inscuteable homolog

  • inscuteable homolog

INSC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INSC Q1MX18 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra
INSC Q1MX18 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
INSC Q1MX18 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
INSC Q1MX18 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
INSC Q1MX18 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
INSC Q1MX18 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
INSC Q1MX18 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
INSC Q1MX18 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
INSC Q1MX18 GPSM2 Homo sapiens P81274
Y2H Array
32296183
Intra
INSC Q1MX18 GPSM2 Homo sapiens P81274
Anti Tag CoIP
33961781
Intra
INSC Q1MX18 GPSM2 Homo sapiens P81274
Y2H Prey Pooling
32296183
Intra
INSC Q1MX18 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
INSC Q1MX18 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
INSC Q1MX18 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra
INSC Q1MX18 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
INSC Q1MX18 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
INSC Q1MX18 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
INSC Q1MX18 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Intra
INSC Q1MX18 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra
INSC Q1MX18 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra
INSC Q1MX18 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145758 FEN1-IN-SC13 Inhibitor 98.42% Unkown
HY-131236 EBNA1-IN-SC7 98.37% Unkown
HY-RS06836 INSC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus INSC RGD RGD:1311379
Bos taurus INSC VGNC VGNC:30216
Macaca mulatta INSC VGNC VGNC:73693
Mus musculus INSC MGD MGI:1917942
Canis familiaris INSC VGNC VGNC:42038
Felis catus INSC VGNC VGNC:62932
Others INSC NCBI