EBNA1-IN-SC7
Based on 1 Customer Validation
EBNA1-IN-SC7 (compound SC7) is a selective Epstein-Barr nuclear antigen 1 (EBNA1) inhibitor that interferes with EBNA1-DNA binding activity with an IC50 value of 23 μM. EBNA1-IN-SC7 is used in EBV (Epstein-Barr virus)-related cancer research.
For research use only. We do not sell to patients.
- Purity: 98.37%
- CAS No.: 324022-08-4
- Formula: C20H16BrNO5S
- Molecular Weight:462.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
EBNA1-IN-SC7 (compound SC7) (5 µM) can completely block transcriptional activation of EBNA1 and show a 60% inhibition of Zta (EBV-encoded b-zip DNA binding protein) trans-activation in HEK293T cells[2].
EBNA1-IN-SC7 (compound SC7) (10 µM, 6 days) has no significant effect on EBV genome copy number of Raji Burkitt lymphoma cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 324022-08-4
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Appearance Solid
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Molecular Weight 462.31
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Formula C20H16BrNO5S
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Color White to light yellow
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SMILES
CC(N(C1=CC=C(OC(C)=O)C(Br)=C1)S(=O)(C2=CC=C3C=CC=CC3=C2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (270.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Lijun Jiang, et al. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics. 2018 Oct 22;8(19):5307-5319. [Content Brief]
[2]. Ning Li, et al. Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening. PLoS One. 2010 Apr 12;5(4):e10126. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1631 mL | 10.8153 mL | 21.6305 mL | 54.0763 mL |
| 5 mM | 0.4326 mL | 2.1631 mL | 4.3261 mL | 10.8153 mL | |
| 10 mM | 0.2163 mL | 1.0815 mL | 2.1631 mL | 5.4076 mL | |
| 15 mM | 0.1442 mL | 0.7210 mL | 1.4420 mL | 3.6051 mL | |
| 20 mM | 0.1082 mL | 0.5408 mL | 1.0815 mL | 2.7038 mL | |
| 25 mM | 0.0865 mL | 0.4326 mL | 0.8652 mL | 2.1631 mL | |
| 30 mM | 0.0721 mL | 0.3605 mL | 0.7210 mL | 1.8025 mL | |
| 40 mM | 0.0541 mL | 0.2704 mL | 0.5408 mL | 1.3519 mL | |
| 50 mM | 0.0433 mL | 0.2163 mL | 0.4326 mL | 1.0815 mL | |
| 60 mM | 0.0361 mL | 0.1803 mL | 0.3605 mL | 0.9013 mL | |
| 80 mM | 0.0270 mL | 0.1352 mL | 0.2704 mL | 0.6760 mL | |
| 100 mM | 0.0216 mL | 0.1082 mL | 0.2163 mL | 0.5408 mL |
EBNA1-IN-SC7 Related Classifications
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