RUSC1 - RUN and SH3 domain containing 1 Gene

Also Known as NESCA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23623

Summary

Predicted to enable Actin binding activity. Involved in protein polyubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in brain (RPKM 8.6), prostate (RPKM 6.2) and 25 other tissues.

RUSC1 Products (8)

mRNA Protein Name
NM_001105203.2 NP_001098673.1 AP-4 complex accessory subunit RUSC1 isoform a
NM_001105204.2 NP_001098674.1 AP-4 complex accessory subunit RUSC1 isoform b
NM_001105205.1 NP_001098675.1 AP-4 complex accessory subunit RUSC1 isoform c
NM_001278227.1 NP_001265156.1 AP-4 complex accessory subunit RUSC1 isoform e
NM_001278228.1 NP_001265157.1 AP-4 complex accessory subunit RUSC1 isoform f
NM_001278229.1 NP_001265158.1 AP-4 complex accessory subunit RUSC1 isoform g
NM_001278230.2 NP_001265159.1 AP-4 complex accessory subunit RUSC1 isoform d
NM_014328.4 NP_055143.2 AP-4 complex accessory subunit RUSC1 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19365808 GOA
Biological Process GO Annotation Evidence References Source
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
19365808 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RUSC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RUSC1 Q9BVN2 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
RUSC1 Q9BVN2 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
RUSC1 Q9BVN2 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
RUSC1 Q9BVN2 TRIM74 Homo sapiens Q86UV6-2
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 TRIM74 Homo sapiens Q86UV6-2
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 CMTM6 Homo sapiens Q9NX76
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 CMTM6 Homo sapiens Q9NX76
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra
RUSC1 Q9BVN2 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra
RUSC1 Q9BVN2 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra
RUSC1 Q9BVN2 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 TBC1D25 Homo sapiens Q3MII6
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 TBC1D25 Homo sapiens Q3MII6
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 VGLL3 Homo sapiens A8MV65-2
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 VGLL3 Homo sapiens A8MV65-2
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 NICN1 Homo sapiens Q9BSH3
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 NICN1 Homo sapiens Q9BSH3
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 N4BP3 Homo sapiens O15049
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 N4BP3 Homo sapiens O15049
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 ABHD5 Homo sapiens Q8WTS1
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 ABHD5 Homo sapiens Q8WTS1
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra
RUSC1 Q9BVN2 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 STUB1 Homo sapiens Q9UNE7
Validated Y2H
25416956
Intra
RUSC1 Q9BVN2 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 MAGEA3 Homo sapiens P43357
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 MAGEA3 Homo sapiens P43357
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
RUSC1 Q9BVN2 RBPMS Homo sapiens Q93062-3
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 RBPMS Homo sapiens Q93062-3
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra
RUSC1 Q9BVN2 DR1 Homo sapiens Q01658
Y2H Array
32814053
Intra
RUSC1 Q9BVN2 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Intra
RUSC1 Q9BVN2 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
RUSC1 Q9BVN2 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
RUSC1 Q9BVN2 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra
RUSC1 Q9BVN2 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RUSC1 Proteins

Cat. No. Product Name Accession Purity
HY-P72842 BACE1 Protein, Human (HEK293, His) NP_036236.1 (T22-T457) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12353 RUSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124499 RUC-1 Inhibitor / Unkown