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MAGED1 - MAGE family member D1 Gene

Also Known as NRAGE; DLXIN-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9500

About MAGED1

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:51,803,076-51,902,354 (from NCBI)

This gene has 10 transcripts (splice variants), 177 orthologues and 37 paralogues. Ubiquitous expression in brain (RPKM 56.4), placenta (RPKM 55.0) and 25 other tissues.

Summary

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MAGED1 Products (3)

mRNA	Protein	Name
NM_001005332.2	NP_001005332.1	melanoma-associated antigen D1 isoform b
NM_001005333.2	NP_001005333.1	melanoma-associated antigen D1 isoform a
NM_006986.4	NP_008917.3	melanoma-associated antigen D1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15930293	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	15930293	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	15930293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGED1 Protein Structure

MAGE

0
200
400
600
778 a.a.

Protein Preferred Names	Protein Names
melanoma-associated antigen D1	MAGE tumor antigen CCF

MAGED1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAGED1	Q9Y5V3	SNRPC	Homo sapiens	Q5TAL4	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	LARP4B	Homo sapiens	Q92615	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	LARP4B	Homo sapiens	Q92615	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	CERCAM	Homo sapiens	Q5T4B2	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	CERCAM	Homo sapiens	Q5T4B2	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	FOXH1	Homo sapiens	O75593	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	CAPN7	Homo sapiens	Q9Y6W3	Validated Y2H	32296183
Intra	MAGED1	Q9Y5V3	SMAP2	Homo sapiens	Q8WU79	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Y2H Array	31515488
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	TFG	Homo sapiens	Q92734	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	SMN1	Homo sapiens	Q16637	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	SMN1	Homo sapiens	Q16637	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	EIF4E2	Homo sapiens	O60573	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Anti Tag CoIP	20864041
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Pull Down	20864041
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	IF	20864041
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Anti Bait CoIP	20864041
Intra	MAGED1	Q9Y5V3	CA8	Homo sapiens	P35219	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	CA8	Homo sapiens	P35219	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	BAG3	Homo sapiens	O95817	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	BAG3	Homo sapiens	O95817	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	CD2BP2	Homo sapiens	O95400	Peptide Array	16000308
Intra	MAGED1	Q9Y5V3	CD2BP2	Homo sapiens	O95400	Protein Array	16000308
Intra	MAGED1	Q9Y5V3	RBM23	Homo sapiens	Q86U06	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	RBM23	Homo sapiens	Q86U06	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	RBM23	Homo sapiens	Q86U06	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	TTC32	Homo sapiens	Q5I0X7	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	TTC32	Homo sapiens	Q5I0X7	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	TTC32	Homo sapiens	Q5I0X7	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	ZNF488	Homo sapiens	Q96MN9	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	ZNF488	Homo sapiens	Q96MN9	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	AKAP9	Homo sapiens	Q99996-2	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	AKAP9	Homo sapiens	Q99996-2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Schaaf-Yang Syndrome	Prader-Willi-Like Syndrome Chitayat-Hall Syndrome SHFYNG Pwls Magel2-Related Prader-Willi-Like Syndrome Magel2-Related Pwls Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies Pws Due To A Point Mutation Pws Due To Point Mutation Prader-Willi Syndrome Due To A Point Mutation Prader-Willi Syndrome Due To Point Mutation Pws-Like

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07976	MAGED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAGED1	MGD	MGI:1930187
Canis familiaris	MAGED1	VGNC	VGNC:42924
Bos taurus	MAGED1	VGNC	VGNC:55062
Rattus norvegicus	MAGED1	RGD	RGD:70898
Macaca mulatta	MAGED1	VGNC	VGNC:74479
Others	MAGED1	NCBI