2. Gene
  3. CD2BP2 - CD2 cytoplasmic tail binding protein 2 Gene

CD2BP2 - CD2 cytoplasmic tail binding protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LIN1; Snu40; FWP010; U5-52K; PPP1R59

Gene ID: 10421 | Gene type: protein coding

About CD2BP2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,350,773-30,355,308 (from NCBI)

This gene has 3 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in brain (RPKM 16.4), lymph node (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

CD2BP2 Products(2)

mRNA Protein Name
NM_001243646.2 NP_001230575.1 CD2 antigen cytoplasmic tail-binding protein 2
NM_006110.3 NP_006101.1 CD2 antigen cytoplasmic tail-binding protein 2

CD2BP2 Protein Structure

GYF

GYF: GYF domain (281 - 338)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

CD2 antigen cytoplasmic tail-binding protein 2

CD2 cytoplasmic domain-binding protein 2

Related Diseases

Diseases Alias
Lobular Neoplasia

Lobular Carcinoma In Situ

Lobular Carcinoma In Situ Of Breast

Lobular Intraepithelial Neoplasia

Non-Infiltrating Lobular Carcinoma

Noninfiltrating Lobular Carcinoma Unspecified Site

Noninfiltrating Lobular Carcinoma Of Breast

Lobular Carcinoma In Situ Unspecified Site
Tolosa-Hunt Syndrome

Painful Ophthalmoplegia

Tolosa Hunt Syndrome

Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure

Ths

Ophthalmoplegia, Painful
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02225 CD2BP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CD2BP2 VGNC VGNC:27023
Canis familiaris CD2BP2 VGNC VGNC:38946
Rattus norvegicus CD2BP2 RGD RGD:1311741
Felis catus CD2BP2 VGNC VGNC:60606
Macaca mulatta CD2BP2 VGNC VGNC:97746
Mus musculus CD2BP2 MGD MGI:1917483