SNRPA - small nuclear ribonucleoprotein polypeptide A Gene

Also Known as U1A; Mud1; U1-A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6626

About SNRPA

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,751,203-40,765,389 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 22.2), lymph node (RPKM 20.2) and 25 other tissues.

Summary

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

SNRPA Products (1)

mRNA Protein Name
NM_004596.5 NP_004587.1 U1 small nuclear ribonucleoprotein A

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding EXP
EXP: Inferred from Experiment
8609632 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
19561594 GOA
enables U1 snRNA binding IDA
IDA: Inferred from direct assay
2147232 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9848648 GOA
Cellular Component GO Annotation Evidence References Source
part of U1 snRNP IDA
IDA: Inferred from direct assay
21113136 GOA
part of U1 snRNP IPI
IPI: Inferred from physical interaction
33677607 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
9731529 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
33677607 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPA Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 82)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (210 - 272)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

U1 small nuclear ribonucleoprotein A

  • U1 small nuclear RNP-specific A

SNRPA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNRPA P09012 ENOX2 Homo sapiens Q16206-2
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 ENOX2 Homo sapiens Q16206-2
Y2H Array
25416956
Intra
SNRPA P09012 NDUFAF3 Homo sapiens Q9BU61-2
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 NDUFAF3 Homo sapiens Q9BU61-2
Y2H Array
25416956
Intra
SNRPA P09012 METTL13 Homo sapiens Q8N6R0
Y2H Array
25416956
Intra
SNRPA P09012 TIAL1 Homo sapiens Q01085-2
Validated Y2H
32296183
Intra
SNRPA P09012 U2AF2 Homo sapiens P26368-2
Validated Y2H
32296183
Intra
SNRPA P09012 U2AF2 Homo sapiens P26368-2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 U2AF2 Homo sapiens P26368-2
Y2H Array
32296183
Intra
SNRPA P09012 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
SNRPA P09012 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
SNRPA P09012 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 PCBP3 Homo sapiens P57721-2
Validated Y2H
32296183
Intra
SNRPA P09012 CHTOP Homo sapiens Q9Y3Y2-3
Validated Y2H
32296183
Intra
SNRPA P09012 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Array
32296183
Intra
SNRPA P09012 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
Intra
SNRPA P09012 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
Intra
SNRPA P09012 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Validated Y2H
32296183
Intra
SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
30886144
Intra
SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
32296183
Intra
SNRPA P09012 FUBP1 Homo sapiens Q96AE4-2
Validated Y2H
32296183
Intra
SNRPA P09012 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
Intra
SNRPA P09012 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 PTBP2 Homo sapiens Q9UKA9-2
Validated Y2H
32296183
Intra
SNRPA P09012 MBNL2 Homo sapiens Q5VZF2-2
Validated Y2H
32296183
Intra
SNRPA P09012 MBNL2 Homo sapiens Q5VZF2-2
Y2H Array
32296183
Intra
SNRPA P09012 MBNL2 Homo sapiens Q5VZF2-2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 TIA1 Homo sapiens P31483
Anti Bait CoIP
12486009
Intra
SNRPA P09012 TIA1 Homo sapiens P31483
Pull Down
12486009
Intra
SNRPA P09012 NDUFAF3 Homo sapiens Q9BU61
Validated Y2H
32296183
Intra
SNRPA P09012 DAZAP1 Homo sapiens Q96EP5
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 DAZAP1 Homo sapiens Q96EP5
Validated Y2H
32296183
Intra
SNRPA P09012 DAZAP1 Homo sapiens Q96EP5
Y2H Array
32296183
Intra
SNRPA P09012 MRPL15 Homo sapiens Q9P015
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 MRPL15 Homo sapiens Q9P015
Validated Y2H
32296183
Intra
SNRPA P09012 MRPL15 Homo sapiens Q9P015
Y2H Array
32296183
Intra
SNRPA P09012 LHX4 Homo sapiens Q969G2
Validated Y2H
32296183
Intra
SNRPA P09012 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
SNRPA P09012 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBM3 Homo sapiens P98179
Validated Y2H
25416956
Intra
SNRPA P09012 RBM3 Homo sapiens P98179
Validated Y2H
32296183
Intra
SNRPA P09012 RBM3 Homo sapiens P98179
Y2H Array
25416956
Intra
SNRPA P09012 RBM3 Homo sapiens P98179
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 RBM3 Homo sapiens P98179
Y2H Array
29892012
Intra
SNRPA P09012 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
Intra
SNRPA P09012 HNRNPK Homo sapiens P61978
Anti Tag CoIP
35271311
Intra
SNRPA P09012 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra
SNRPA P09012 RASAL3 Homo sapiens Q86YV0
Validated Y2H
32296183
Intra
SNRPA P09012 RASAL3 Homo sapiens Q86YV0
Y2H Array
32296183
Intra
SNRPA P09012 RASAL3 Homo sapiens Q86YV0
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 DDX39B Homo sapiens Q13838
Anti Tag CoIP
35271311
Intra
SNRPA P09012 DDX39B Homo sapiens Q13838
Validated Y2H
32296183
Intra
SNRPA P09012 PTBP1 Homo sapiens P26599
Y2H Array
31515488
Intra
SNRPA P09012 PTBP1 Homo sapiens P26599
Validated Y2H
25416956
Intra
SNRPA P09012 HNRNPU Homo sapiens Q00839
Anti Tag CoIP
35271311
Intra
SNRPA P09012 HNRNPU Homo sapiens Q00839
Crosslink
30021884
Intra
SNRPA P09012 SFPQ Homo sapiens P23246
Anti Tag CoIP
35271311
Intra
SNRPA P09012 SFPQ Homo sapiens P23246
Anti Bait CoIP
9848648
Intra
SNRPA P09012 CIRBP Homo sapiens Q14011
Validated Y2H
25416956
Intra
SNRPA P09012 CIRBP Homo sapiens Q14011
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 CIRBP Homo sapiens Q14011
Y2H Array
25416956
Intra
SNRPA P09012 SNRPA1 Homo sapiens P09661
Y2H
22365833
Intra
SNRPA P09012 SNRPA1 Homo sapiens P09661
Anti Tag CoIP
35271311
Intra
SNRPA P09012 SNRPA1 Homo sapiens P09661
Validated Y2H
32296183
Intra
SNRPA P09012 SNRPA1 Homo sapiens P09661
Validated Y2H
25416956
Intra
SNRPA P09012 GABPB1 Homo sapiens Q06547
Y2H Array
25416956
Intra
SNRPA P09012 HNRNPK Homo sapiens P61978-2
Validated Y2H
32296183
Intra
SNRPA P09012 RBM4B Homo sapiens Q9BQ04
Validated Y2H
32296183
Intra
SNRPA P09012 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
SNRPA P09012 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
SNRPA P09012 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
Intra
SNRPA P09012 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra
SNRPA P09012 LENG8 Homo sapiens Q96PV6
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 LENG8 Homo sapiens Q96PV6
Anti Tag CoIP
35271311
Intra
SNRPA P09012 LENG8 Homo sapiens Q96PV6
Validated Y2H
25416956
Intra
SNRPA P09012 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
SNRPA P09012 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
SNRPA P09012 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBM11 Homo sapiens P57052
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBM11 Homo sapiens P57052
Validated Y2H
32296183
Intra
SNRPA P09012 RBM11 Homo sapiens P57052
Y2H Array
32296183
Intra
SNRPA P09012 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
SNRPA P09012 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
SNRPA P09012 U2AF2 Homo sapiens P26368
Anti Tag CoIP
22365833
Intra
SNRPA P09012 U2AF2 Homo sapiens P26368
Validated Y2H
25416956
Intra
SNRPA P09012 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 RBMX Homo sapiens P38159
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 RBMX Homo sapiens P38159
Anti Tag CoIP
35271311
Intra
SNRPA P09012 TRIR Homo sapiens Q9BQ61
Validated Y2H
32296183
Intra
SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H Array
32296183
Intra
SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H
22365833
Intra
SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H Pooling
16189514
Intra
SNRPA P09012 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 TNFAIP8L1 Homo sapiens Q8WVP5
Validated Y2H
32296183
Intra
SNRPA P09012 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Array
32296183
Intra
SNRPA P09012 CD2BP2 Homo sapiens O95400
Anti Tag CoIP
35271311
Intra
SNRPA P09012 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 RBMY1F Homo sapiens Q15415
Validated Y2H
32296183
Intra
SNRPA P09012 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Intra
SNRPA P09012 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra
SNRPA P09012 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 OTX2 Homo sapiens P32243-2
Validated Y2H
32296183
Intra
SNRPA P09012 QKI Homo sapiens Q96PU8
Validated Y2H
25416956
Intra
SNRPA P09012 QKI Homo sapiens Q96PU8
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 PCBP2 Homo sapiens Q15366
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 PCBP2 Homo sapiens Q15366
Y2H Array
25416956
Intra
SNRPA P09012 PCBP1 Homo sapiens Q15365
Validated Y2H
25416956
Intra
SNRPA P09012 PCBP1 Homo sapiens Q15365
Validated Y2H
32296183
Intra
SNRPA P09012 PCBP1 Homo sapiens Q15365
Y2H Prey Pooling
25416956
Intra
SNRPA P09012 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra
SNRPA P09012 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Intra
SNRPA P09012 ZCCHC13 Homo sapiens Q8WW36
Validated Y2H
32296183
Intra
SNRPA P09012 ZCCHC13 Homo sapiens Q8WW36
Y2H Array
32296183
Intra
SNRPA P09012 ZCCHC13 Homo sapiens Q8WW36
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SNRPA Antibodies

Cat. No. Product Name Application Reactivity
HY-P82015 U1A Antibody (YA1760) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Mixed Connective Tissue Disease

  • Sharp Syndrome

  • Mctd

  • Connective Tissue Disease Overlap Syndrome

  • Mixed Collagen Vascular Disease

  • Mctd - [Mixed Connective Tissue Disease]
Premature Ovarian Failure 18

  • POF18

  • Primary Ovarian Insufficiency 18

  • Ovarian Failure, Premature, Type 18
Connective Tissue Disease

  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Mucopolysaccharidosis, Type Iiia

  • Mucopolysaccharidosis Type Iiia

  • MPS3A

  • Mps Iiia

  • Sanfilippo Syndrome A

  • Heparan Sulfate Sulfatase Deficiency

  • Sulfamidase Deficiency

  • Heparan Sulfamidase Deficiency

  • Mpsiiia

  • Mucopolysaccharidosis Type 3a

  • Sanfilippo Syndrome Type A

  • Mucopolysaccharidosis Iii-A

  • Heparane Sulfamidase Deficiency

  • Mps 3a

  • Mucopoly-Saccharidosis Type 3a

  • Mps Iii-A

  • Mucopolysaccharidosis 3a

  • Mucopolysaccharidosis Iii
Mucopolysaccharidosis Iii

  • Sanfilippo Syndrome

  • Mucopolysaccharidosis Type Iii

  • Mucopolysaccharidosis Type 3

  • Mps Iii

  • Mpsiii

  • Sanfilippo Disease

  • Heparan Sulfate Sulfatase Deficiency

  • Mucopolysaccharidosis, Mps-Iii

  • N-Sulphoglucosamine Sulphohydrolase Deficiency

  • Naglu Deficiency

  • Sanfilippo'S Syndrome

  • Mucopoly-Saccharidosis Type 3

  • Mps3

  • Sanfilippos Syndrome

  • Mucopolysaccharidosis Type Iiia

  • Mps Iii B
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13500 SNRPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13501 SNRPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19482 Snrpa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SNRPA VGNC VGNC:97639
Macaca mulatta SNRPA VGNC VGNC:77674
Bos taurus SNRPA VGNC VGNC:35074
Mus musculus SNRPA MGD MGI:1855690
Rattus norvegicus SNRPA RGD RGD:1307416
Others SNRPA NCBI