RBM11 - RNA binding motif protein 11 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54033

About RBM11

Cytogenetic location: 21q11.2 Genomic coordinates (GRCh38): 21:14,216,157-14,228,372 (from NCBI)

This gene has 6 transcripts (splice variants), 135 orthologues and 1 paralogue. Broad expression in ovary (RPKM 1.3), thyroid (RPKM 1.3) and 21 other tissues.

Summary

Enables poly(U) RNA binding activity and protein homodimerization activity. Acts upstream of or within cellular response to oxidative stress and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

RBM11 Products (2)

mRNA Protein Name
NM_001320602.2 NP_001307531.1 splicing regulator RBM11 isoform 2
NM_144770.5 NP_658983.3 splicing regulator RBM11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
21984414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
21984414 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to oxidative stress IDA
IDA: Inferred from direct assay
21984414 GOA
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
21984414 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
21984414 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
21984414 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21984414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM11 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 80)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

splicing regulator RBM11

  • putative RNA-binding protein 11

RBM11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBM11 P57052 ZFHX3 Homo sapiens Q15911-2
Validated Y2H
32296183
Intra
RBM11 P57052 SNRPC Homo sapiens Q5TAL4
Validated Y2H
25416956
Intra
RBM11 P57052 SNRPC Homo sapiens Q5TAL4
Y2H Prey Pooling
25416956
Intra
RBM11 P57052 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
RBM11 P57052 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
RBM11 P57052 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
RBM11 P57052 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra
RBM11 P57052 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
RBM11 P57052 ZCCHC8 Homo sapiens Q6NZY4
Anti Tag CoIP
28514442
Intra
RBM11 P57052 ZCCHC8 Homo sapiens Q6NZY4
Y2H Fragment Pooling
35914814
Intra
RBM11 P57052 ZCCHC8 Homo sapiens Q6NZY4
Anti Tag CoIP
33961781
Intra
RBM11 P57052 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
RBM11 P57052 GADD45GIP1 Homo sapiens Q8TAE8
Validated Y2H
32296183
Intra
RBM11 P57052 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
RBM11 P57052 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
RBM11 P57052 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
RBM11 P57052 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
RBM11 P57052 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
RBM11 P57052 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
RBM11 P57052 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
RBM11 P57052 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
RBM11 P57052 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
RBM11 P57052 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
Intra
RBM11 P57052 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
RBM11 P57052 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
RBM11 P57052 ZNF414 Homo sapiens Q96IQ9
Validated Y2H
32296183
Intra
RBM11 P57052 ATOSB Homo sapiens Q7L5A3
Validated Y2H
32296183
Intra
RBM11 P57052 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
RBM11 P57052 PRPH Homo sapiens P41219
Y2H Pooling
32814053
Intra
RBM11 P57052 PRPH Homo sapiens P41219
Validated Y2H
32814053
Intra
RBM11 P57052 PRPH Homo sapiens P41219
Y2H Array
32814053
Intra
RBM11 P57052 QKI Homo sapiens Q96PU8
Y2H Array
25416956
Intra
RBM11 P57052 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
Intra
RBM11 P57052 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
Intra
RBM11 P57052 FLNA Homo sapiens P21333-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11732 RBM11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RBM11 VGNC VGNC:76681
Rattus norvegicus RBM11 RGD RGD:1305195
Canis familiaris RBM11 VGNC VGNC:45405
Mus musculus RBM11 MGD MGI:2447622
Felis catus RBM11 VGNC VGNC:69263
Bos taurus RBM11 VGNC VGNC:33784
Others RBM11 NCBI