DTX2 - deltex E3 ubiquitin ligase 2 Gene

Homo sapiens

Also known as RNF58

Gene ID: 113878 | Gene type: protein coding

About DTX2

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,461,709-76,505,991 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 208 orthologues and 4 paralogues. Broad expression in esophagus (RPKM 8.4), testis (RPKM 7.2) and 25 other tissues.

Summary

DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX2 Products(4)

mRNA	Protein	Name
NM_001102594.3	NP_001096064.1	probable E3 ubiquitin-protein ligase DTX2 isoform a
NM_001102595.3	NP_001096065.1	probable E3 ubiquitin-protein ligase DTX2 isoform a
NM_001102596.2	NP_001096066.1	probable E3 ubiquitin-protein ligase DTX2 isoform b
NM_020892.4	NP_065943.2	probable E3 ubiquitin-protein ligase DTX2 isoform a

DTX2 Protein Structure

WWE

zf-C3HC4

0
100
200
300
400
500
622 a.a.

Protein Preferred Names

Protein Names

probable E3 ubiquitin-protein ligase DTX2

RING-type E3 ubiquitin transferase DTX2

Related Diseases

Diseases

Alias

Pthirus Pubis Infestation

Infestation By Phthirus Pubis	Crabs
Pediculosis Pubis	Pediculus Pubis
Phthiriasis Pubis	Phthirus Pubis
Phthirus/Pediculus Pubis - Pubic Lice - Crabs

Cutaneous Diphtheria

Diphtheria Wound Infection

Hypotrichosis 12

HYPT12

Hypotrichosis, Type 12

Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma

Atrophic Muscular Disease

Muscular Disorders, Atrophic

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

Cauda Equina Syndrome

Cauda Equina

Polyradiculopathy

Lice Infestation

Pediculosis	Louse Infestation
Mixed Pediculosis	Lice Infestations
Infestation By Pediculus	Mixed Pediculosis Infestation
Pediculosis + Lice	Pediculosis And Phthirus Infection
Pediculosis And Phthirus Infections	Pediculosis And Phthirus Infestation
Infestation By Anoplura	Pediculus Infestation
Lice Nos

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04039	DTX2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DTX2	VGNC	VGNC:40116
Mus musculus	DTX2	MGD	MGI:1921448
Macaca mulatta	DTX2	VGNC	VGNC:71843
Bos taurus	DTX2	VGNC	VGNC:28237
Felis catus	DTX2	VGNC	VGNC:61649
Rattus norvegicus	DTX2	RGD	RGD:1561790