HDC - histidine decarboxylase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3067

About HDC

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:50,241,947-50,265,726 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues, 7 paralogues and is associated with 2 phenotypes. Broad expression in gall bladder (RPKM 9.0), stomach (RPKM 6.4) and 14 other tissues.

Summary

This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

HDC Products (2)

mRNA Protein Name
NM_001306146.2 NP_001293075.1 histidine decarboxylase isoform 2
NM_002112.4 NP_002103.2 histidine decarboxylase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histidine decarboxylase activity IDA
IDA: Inferred from direct assay
22767596 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in L-histidine catabolic process IDA
IDA: Inferred from direct assay
22767596 GOA
involved in histamine biosynthetic process IDA
IDA: Inferred from direct assay
22767596 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDC Protein Structure

Pyridoxal_deC

Pyridoxal_deC: Pyridoxal-dependent decarboxylase conserved domain (36 - 414)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

histidine decarboxylase

HDC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HDC P19113 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra
HDC P19113 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gilles De La Tourette Syndrome

  • Tourette Syndrome

  • Tourette Disorder

  • GTS

  • Ts

  • Gilles De La Tourette'S Syndrome

  • Motor-Verbal Tic Disorder

  • Guinon'S Disease

  • Psychogenic Tics

  • Tourette'S Syndrome

  • Chronic Motor And Vocal Tic Disorder

  • Td

  • Tourette'S Disease

  • Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

  • Combined Vocal And Multiple Motor Tic Disorder

  • Tic De La Tourette
Mast Cell Neoplasm

  • Mastocytoma

  • Mast Cell Proliferative Disease

  • Mast Cell Tumor

  • Benign Mastocytoma
Systemic Mastocytosis

  • Systemic Mast Cell Disease

  • Systemic Tissue Mast Cell Disease

  • Mastocytosis, Systemic

  • Smcd - Systemic Mast Cell Disease

  • Smcd

  • Mast Cell Disease, Systemic

  • Systemic Mast-Cell Disease

  • Systemic Mastocytoses

  • Mastocytosis Systemic

  • Corneal Dystrophy, Subepithelial Mucinous

  • Smcd - [Systemic Mast Cell Disease]
Metal Allergy
Mastocytosis

  • Mast Cell Disease

  • Mast Cell Hyperplasia

  • Urticaria Pigmentosa

  • Malignant Mastocytoma

  • Malignant Mast Cell Tumours

  • Malignant Mastocytosis
Stomach Disease

  • Gastropathy

  • Stomach Diseases

  • Gastric Disease

  • Stomach Disorder

  • Gastric Disorder

  • Stomach Disorders
Tic Disorder

  • Tics

  • Behavioral Tic
Peptic Ulcer Disease

  • Peptic Ulcer

  • Acute Peptic Ulcer With Hemorrhage

  • Acute Peptic Ulcer With Hemorrhage And Perforation

  • Acute Peptic Ulcer Without Hemorrhage And Without Perforation
Vestibular Nystagmus

  • Nystagmus Associated With Disorder Of The Vestibular System
Intestinal Obstruction

  • Inspissated Milk Syndrome

  • Milk Curd Syndrome
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W003445 4-Bromo-3-hydroxybenzoic acid 99.25% Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-186122 CCK2R agonist-1 Agonist / Unkown
HY-RS06091 HDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06106 HECA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W194107 Antitumor agent-152 Inhibitor / Unkown
HY-RS17727 Hdc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24192 Hdc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HDC VGNC VGNC:41625
Rattus norvegicus HDC RGD RGD:2790
Macaca mulatta HDC VGNC VGNC:73360
Mus musculus HDC MGD MGI:96062
Felis catus HDC VGNC VGNC:67550
Bos taurus HDC VGNC VGNC:29784
Others HDC NCBI