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Cat. No.: HY-W194107

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Antitumor agent-152

Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of ³H-dC in L1210 leukemia cells with an IC₅₀ value of 1.12 μM.

For research use only. We do not sell to patients.

CAS No.: 1209784-87-1
Formula: C₁₇H₁₉N₅O₂S₂
Molecular Weight:389.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antitumor agent-152 Chemical Structure

CAS No.: 1209784-87-1

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Biological Activity
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- Cellular Effect
Chemical Information
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References
Calculators
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	1.12 μM Compound: 5	Inhibition of dCK in mouse L1210 cells assessed as inhibition of tritiated deoxycytidine [3H]-dC uptake Inhibition of dCK in mouse L1210 cells assessed as inhibition of tritiated deoxycytidine [3H]-dC uptake	[PMID: 23947754]

Chemical Information

CAS No. 1209784-87-1
Molecular Weight 389.50
Formula C₁₇H₁₉N₅O₂S₂
SMILES

NC1=NC(SCC2=CSC(C3=CC=C(OCC)C(OC)=C3)=N2)=NC(N)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Murphy JM, et al. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013;56(17):6696-6708. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
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References

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Antitumor agent-152

High-Throughput Bioactive Compound Library

All DNA/RNA Synthesis Isoforms