1209784-87-1
1209784-87-1
Chemical Structure
Antitumor agent-152
- CAS No.: 1209784-87-1
- Formula:C17H19N5O2S2
- Molecular Weight:389.50
IUPAC Name: 2-(((2-(4-ethoxy-3-methoxyphenyl)thiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine
InChIKey: RCRHRBBNZAVXQG-UHFFFAOYSA-N
SMILES: NC1=NC(SCC2=CSC(C3=CC=C(OCC)C(OC)=C3)=N2)=NC(N)=C1
Biological Activity: Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM[1].
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Antitumor agent-152 | Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM. | |||||||||||||||||||||
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