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By Targets:	5-HT Receptor (2) Adenosine Receptor (1) GLUT (1) Histone Demethylase (2) mTOR (1) Notch (2) Parasite (1) PKC (1) Progesterone Receptor (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19946

Eptapirone F 11440	5-HT Receptor	Neurological Disease
Eptapirone (F11440) is a potent, selective and orally active 5-HT_1A receptor agonist (pK_i = 8.33). Eptapirone can inhibit cAMP production. Eptapirone can reduce 5-HT levels and increase corticosterone levels. Eptapirone shows potent anxiolytic and antidepressant potential. Eptapirone can be used for the research of neurological disease, such as anxiety and depression .

HY-19946A

Eptapirone fumarate F 11440 fumarate	5-HT Receptor	Neurological Disease
Eptapirone fumarate (F11440 fumarate) is a potent, selective and orally active 5-HT_1A receptor agonist (pK_i = 8.33). Eptapirone fumarate can inhibit cAMP production. Eptapirone fumarate can reduce 5-HT levels and increase corticosterone levels. Eptapirone fumarate shows potent anxiolytic and antidepressant potential. Eptapirone fumarate can be used for the research of neurological disease, such as anxiety and depression .

HY-117127

Clogestone acetate AY-11440	Progesterone Receptor	Others
Clogestone acetate (AY-11440) is an orally active progesterone receptor agonist. Clogestone acetate reduces adrenal and ovarian weight, as well as serum and adrenocortical ketone levels in rats .

HY-133838

Ilmofosine BM41440	Parasite PKC	Infection Cancer
Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent .

HY-123038

CVT-5440	Adenosine Receptor	Inflammation/Immunology
CVT-5440 is a xanthine based, selective, high affinity A_2B adenosine receptors (AdoR) antagonist with a K_i of 50 nM (selectivity A₁> 200; A_2A>200; A₃>167). CVT-5440 has the potential for asthma research .

HY-183067

TAS1440	Histone Demethylase TGF-beta/Smad Notch	Cancer
TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC₅₀ of 4.8 nM. TAS1440 non-covalently binds to the histone H₃-binding pocket of LSD1, inhibiting demethylase activity and disrupting repressive complexes with INSM1 and SMAD2. TAS1440 activates tumor-suppressive TGF-β and NOTCH signaling pathways via transcriptional reprogramming. TAS1440 can be used for the research of small cell lung cancer, specifically the SCLC-A subtype .

HY-138976

NV-5440	mTOR GLUT	Neurological Disease Metabolic Disease Cancer
NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake .

HY-183067A

TAS1440 benzoate	Histone Demethylase TGF-beta/Smad Notch	Cancer
TAS1440 benzoate is an orally active LSD1/KDM1A inhibitor with a human IC₅₀ of 4.8 nM. TAS1440 benzoate non-covalently binds to the histone H3-binding pocket of LSD1, inhibiting demethylase activity and disrupting repressive complexes with INSM1 and SMAD2. TAS1440 benzoate activates tumor-suppressive TGF-β and NOTCH signaling pathways via transcriptional reprogramming. TAS1440 benzoate can be used for the research of small cell lung cancer, specifically the SCLC-A subtype .

Species:	E.coli (2)
Tag:	SUMO (2) His (2)
Source:	E. coli Cell-free (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701313

	MCR-1 Protein, E.coli (Cell-Free, His-SUMO) mcr1; mcr-1; APZ14_31440; Probable phosphatidylethanolamine transferase Mcr-1; EC 2.7.-.-; Polymyxin resistance protein MCR-1	E.coli	E. coli Cell-free
	The MCR-1 protein may catalyze the addition of a phosphoethanolamine moiety to lipid A, which is associated with polymyxin resistance. This modification observed in E. coli expressing MCR-1 increased the minimum inhibitory concentration (MIC) of colistin and polymyxin B. MCR-1 Protein, E.coli (Cell-Free, His-SUMO) is the recombinant E. coli-derived MCR-1 protein, expressed by E. coli Cell-free , with labeled tag.

HY-P71578

	MCR-1 protein, E.coli (364a.a, His-SUMO) mcr1; mcr-1; APZ14_31440; Probable phosphatidylethanolamine transferase Mcr-1; EC 2.7.-.-; Polymyxin resistance protein MCR-1	E.coli	E. coli
	The MCR-1 protein may catalyze the addition of a phosphoethanolamine moiety to lipid A, which is associated with polymyxin resistance. This modification observed in E. coli expressing MCR-1 increased the minimum inhibitory concentration (MIC) of colistin and polymyxin B. MCR-1 protein, E.coli (364a.a, His-SUMO) is the recombinant E. coli-derived MCR-1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Bovine (1) Rat (1) Mouse (2) Rabbit (2) Zebrafish (1) Chicken (1) Pig (1)
Application:	IHC-P (1) ICC/IF (2) WB (5) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Phosphorylated (1) Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81695

	Phospho-Nucleolin (Thr84) Antibody (YA1440) C23; Nsr1	WB	Human
	Phospho-Nucleolin (Thr84) Antibody (YA1440) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Nucleolin (Thr84).

HY-P81695A

	Phospho-Nucleolin (Thr84) Antibody (YA1440)(PBS only) C23; Nsr1	WB	Human
	Phospho-Nucleolin (Thr84) Antibody (YA1440) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Nucleolin (Thr84).

HY-P85452

	PP1C alpha Antibody (YA5144) PPP1CA; PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A	WB, ICC/IF	Human, Mouse, Rat, Bovine, Chicken, Pig, Rabbit, Zebrafish
	PP1C alpha Antibody (YA5144) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PP1C alpha.

HY-P85448

	Pyruvate Dehydrogenase E2 Antibody (YA5140) DLAT; DLTA; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruva	WB	Human, Rabbit
	Pyruvate Dehydrogenase E2 Antibody (YA5140) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P85748

	Galectin-3 Antibody (YA5440) LGALS3; MAC2; Galectin-3; Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	Galectin-3 Antibody (YA5440) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Galectin-3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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