HLX - H2.0 like homeobox Gene

Also Known as HB24; HLX1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3142

About HLX

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,879,443-220,885,059 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 18.6), fat (RPKM 10.7) and 19 other tissues.

Summary

Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

HLX Products (1)

mRNA Protein Name
NM_021958.4 NP_068777.1 H2.0-like homeobox protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9073066 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLX Protein Structure

Homeobox

Homeobox: Homeobox domain (279 - 333)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

H2.0-like homeobox protein

  • H2.0-like homeo box-1

HLX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HLX Q14774 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra
HLX Q14774 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HLX Q14774 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
HLX Q14774 MIEN1 Homo sapiens Q9BRT3
Validated Y2H
32296183
Intra
HLX Q14774 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
HLX Q14774 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HLX Antibodies

Cat. No. Product Name Application Reactivity
HY-P811182 HLX Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P85434 HLX1 Antibody (YA5126) WB Human, Mouse, Rat, Bovine, Dog, Pig

Related Diseases

Diseases Alias
Diaphragmatic Hernia-Short Bowel-Asplenia Syndrome
Diaphragmatic Eventration
Osteogenesis Imperfecta, Type Xi

  • Osteogenesis Imperfecta Type 11

  • OI11

  • Osteogenesis Imperfecta Type Xi

  • Oi, Type Xi

  • Osteogenesis Imperfecta 11

  • Oi Type Xi

  • Oi-Xi
Diaphragm Disease

  • Abnormality Of The Diaphragm

  • Disease Of Diaphragm

  • Diaphragmatic Disorder

  • Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

  • Congenital Diaphragmatic Hernia

  • Diaphragmatic Hernia

  • Cdh

  • Congenital Diaphragmatic Defect

  • Hernia, Diaphragmatic

  • Dih

  • Hernia, Congenital Diaphragmatic

  • Hcd

  • Diaphragmatic Defect, Congenital

  • Diaphragm, Unilateral Agenesis Of

  • Hemidiaphragm, Agenesis Of

  • Diaphragmatic Hernia 1

  • Agenesis Of Hemidiaphragm

  • Unilateral Agenesis Of Diaphragm

  • Hernia Diaphragmatic

  • Hernia Diaphragmatic Congenital

  • Hernia, Diaphragmatic, Type 1

  • Hiatus Hernia

  • Oesophageal Hiatus Hernia

  • Paraoesophageal Hernia

  • Sliding Hiatus Hernia

  • Congenital Diaphragm Hernia

  • Congenital Diaphragm Defect With Hernia

  • Gross Congenital Diaphragm Defect
Patent Foramen Ovale

  • Atrial Septal Defect Within Oval Fossa

  • Foramen Ovale Patent

  • Ostium Secundum Atrial Septal Defect

  • Atrial Septal Defect, Ostium Secundum Type

  • Foramen Ovale, Patent

  • Defect, Patent Or Persistent, Ostium Secundum

  • Ostium Secundum Type Atrial Septal Defect

  • Persistent Ostium Secundum

  • Asd Ostium Secundum Type

  • Ostium Secundum Asd

  • Osasd

  • Asd, Ostium Secundum Type

  • Pfo - [Patent Foramen Ovale]

  • Open Foramen Ovale

  • Open Oval Foramen

  • Persistent Foramen Ovale

  • Secundum Atrial Septal Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99118 Serplulimab 99.30% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-177439 HLX43 Inhibitor 99.60% Phase 3
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P991588 HLX-22 99.47% Phase 3
HY-P991605 HLX26 Inhibitor / Phase 2
HY-P99785 Opucolimab Inhibitor 99.18% Phase 1
HY-P99516 Vulinacimab Inhibitor 99.40% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123773 SR-16157 / Unkown
HY-RS06221 HLX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992368 HLX51 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HLX MGD MGI:96109
Macaca mulatta HLX VGNC VGNC:106382
Canis familiaris HLX VGNC VGNC:50302
Rattus norvegicus HLX RGD RGD:1311961
Bos taurus HLX VGNC VGNC:50277
Felis catus HLX VGNC VGNC:107879
Others HLX NCBI