2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. HLX-22

HLX-22  (Synonyms: AC101)

Cat. No.: HY-P991588 Purity: 99.47%
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HLX-22 is a humanized monoclonal antibody targeting HER2. HLX-22 induces apoptosis in HER2-overexpressing breast and gastric cancer cells combined with Trastuzumab (HY-P9907). HLX-22 has potent antitumor activity against advanced solid tumors.

For research use only. We do not sell to patients.

HLX-22

HLX-22 Chemical Structure

CAS No. : 2851060-90-5

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Based on 1 publication(s) in Google Scholar

HLX-22 Related Antibodies

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  • Purity & Documentation

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Description

HLX-22 is a humanized monoclonal antibody targeting HER2. HLX-22 induces apoptosis in HER2-overexpressing breast and gastric cancer cells combined with Trastuzumab (HY-P9907). HLX-22 has potent antitumor activity against advanced solid tumors[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

HER2

 

In Vitro

Combined treatment with HLX22 and Trastuzumab (HY-P9907) inhibits growth and enhances apoptosis in HER2-overexpressing breast cancer cells and gastric cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HLX-22 Related Antibodies
In Vivo

Combined treatment with HLX22 and Trastuzumab (HY-P9907) inhibits growth in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Gene ID

2064  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

144.18 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

N/A
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HLX-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HLX-222851060-90-5AC101HLX22HLX 22AC 101AC-101EGFRApoptosisEpidermal growth factor receptorErbB-1HER1XELOXHER2-overexpressing solid tumorsHER2HER2-overexpressing breast cancer cellstrastuzumabHER2-positive advanced gastric/gastroesophageal junction cancerHLX02gastric cancer cellsInhibitorinhibitorinhibit

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