2851060-90-5
2851060-90-5
Chemical Structure
HLX-22
Synonym(s): AC101
- CAS No.: 2851060-90-5
- Formula:N/A
- Molecular Weight:(144.18 kDa)
SMILES: N/A
Biological Activity: HLX-22 is a humanized monoclonal antibody targeting HER2. HLX-22 induces apoptosis in HER2-overexpressing breast and gastric cancer cells combined with Trastuzumab (HY-P9907). HLX-22 has potent antitumor activity against advanced solid tumors[1][2].
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HLX-22 | 99.47% | HLX-22 is a humanized monoclonal antibody targeting HER2. HLX-22 induces apoptosis in HER2-overexpressing breast and gastric cancer cells combined with Trastuzumab (HY-P9907). HLX-22 has potent antitumor activity against advanced solid tumors. | ||||||||||||||||||||
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References
- [1]. Gao Y, Li N, Qiu M, et al. 422P HLX22 plus HLX02 and XELOX as first-line therapy for HER2-positive advanced gastric/gastroesophageal junction cancer: Updated results from a randomized, double-blind phase II study[J]. Annals of Oncology, 2024, 35: S171-S172.
- [2]. Zhu X, et al. HLX22, an anti-HER-2 monoclonal antibody, in patients with advanced solid tumors overexpressing human epidermal growth factor receptor 2: an open-label, dose-escalation, phase 1 trial. Invest New Drugs. 2023;41(3):473-482. [Content Brief]
Keywords
