MIEN1 - migration and invasion enhancer 1 Gene

Also Known as C35; ORB3; XTP4; RDX12; C17orf37

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84299

About MIEN1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,728,510-39,730,532 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 15.4), esophagus (RPKM 14.3) and 25 other tissues.

Summary

Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MIEN1 Products (2)

mRNA Protein Name
NM_001330206.2 NP_001317135.1 migration and invasion enhancer 1 isoform 2
NM_032339.5 NP_115715.3 migration and invasion enhancer 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
21068479 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
21628459 GOA
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
21628459 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
21628459 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21628459 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIEN1 Protein Structure

Rdx

Rdx: Rdx family (24 - 95)

  • 0
  • 100
  • 115 a.a.
Protein Preferred Names Protein Names

migration and invasion enhancer 1

  • HBV X-transactivated gene 4 protein

MIEN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MIEN1 Q9BRT3 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 VENTX Homo sapiens O95231
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 VENTX Homo sapiens O95231
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 HDAC7 Homo sapiens Q8WUI4-6
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 HDAC7 Homo sapiens Q8WUI4-6
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
MIEN1 Q9BRT3 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
MIEN1 Q9BRT3 HLX Homo sapiens Q14774
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 HLX Homo sapiens Q14774
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
MIEN1 Q9BRT3 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra
MIEN1 Q9BRT3 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Large Cell Neuroendocrine Carcinoma
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08441 MIEN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19715 Mien1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26211 Mien1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MIEN1 VGNC VGNC:63499
Mus musculus MIEN1 MGD MGI:1913678
Bos taurus MIEN1 VGNC VGNC:31468
Rattus norvegicus MIEN1 RGD RGD:1306682
Canis familiaris MIEN1 VGNC VGNC:43228
Others MIEN1 NCBI