ARID5A - AT-rich interaction domain 5A Gene

Also Known as MRF1; MRF-1; RP11-363D14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10865

About ARID5A

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,536,752-96,552,638 (from NCBI)

This gene has 7 transcripts (splice variants), 137 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 12.1), appendix (RPKM 8.5) and 24 other tissues.

Summary

Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

ARID5A Products (7)

mRNA Protein Name
NM_001319085.2 NP_001306014.1 AT-rich interactive domain-containing protein 5A isoform a
NM_001319087.2 NP_001306016.1 AT-rich interactive domain-containing protein 5A isoform b
NM_001319092.1 NP_001306021.1 AT-rich interactive domain-containing protein 5A isoform d
NM_001319093.2 NP_001306022.1 AT-rich interactive domain-containing protein 5A isoform e
NM_001319094.2 NP_001306023.1 AT-rich interactive domain-containing protein 5A isoform e
NM_001319096.2 NP_001306025.1 AT-rich interactive domain-containing protein 5A isoform e
NM_212481.3 NP_997646.1 AT-rich interactive domain-containing protein 5A isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
32209697 GOA
enables nuclear androgen receptor binding IDA
IDA: Inferred from direct assay
15941852 GOA
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
15941852 GOA
enables nuclear retinoid X receptor binding IDA
IDA: Inferred from direct assay
15941852 GOA
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
15941852 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15941852 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15640446 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15941852 GOA
enables transcription factor binding IDA
IDA: Inferred from direct assay
15941852 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
15941852 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15941852 GOA
involved in positive regulation of 3'-UTR-mediated mRNA stabilization IMP
IMP: Inferred from mutant phenotype
32209697 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARID5A Protein Structure

ARID

ARID: ARID/BRIGHT DNA binding domain (53 - 142)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

AT-rich interactive domain-containing protein 5A

  • ARID domain-containing protein 5A

ARID5A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARID5A Q03989 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 KRTAP12-2 Homo sapiens P59991
Y2H Array
25416956
Intra
ARID5A Q03989 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 ESRP1 Homo sapiens Q6NXG1
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 ESRP1 Homo sapiens Q6NXG1
Validated Y2H
32296183
Intra
ARID5A Q03989 ESRP1 Homo sapiens Q6NXG1
Y2H Array
32296183
Intra
ARID5A Q03989 OLIG3 Homo sapiens Q7RTU3
Validated Y2H
32296183
Intra
ARID5A Q03989 OLIG3 Homo sapiens Q7RTU3
Complementation
32296183
Intra
ARID5A Q03989 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 TRIM74 Homo sapiens Q86UV6-2
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
ARID5A Q03989 NUDT22 Homo sapiens Q9BRQ3
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32296183
Intra
ARID5A Q03989 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra
ARID5A Q03989 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
ARID5A Q03989 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 ZIC1 Homo sapiens Q15915
Validated Y2H
32296183
Intra
ARID5A Q03989 ACTMAP Homo sapiens Q5BKX5-3
Validated Y2H
32296183
Intra
ARID5A Q03989 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
ARID5A Q03989 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 BOLL Homo sapiens Q8N9W6-4
Validated Y2H
32296183
Intra
ARID5A Q03989 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra
ARID5A Q03989 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
Intra
ARID5A Q03989 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP15-1 Homo sapiens Q3LI76
Validated Y2H
32296183
Intra
ARID5A Q03989 KDF1 Homo sapiens Q8NAX2
Validated Y2H
32296183
Intra
ARID5A Q03989 PLEKHN1 Homo sapiens Q494U1-3
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP19-3 Homo sapiens Q7Z4W3
Validated Y2H
32296183
Intra
ARID5A Q03989 KAZN Homo sapiens Q674X7-2
Validated Y2H
32296183
Intra
ARID5A Q03989 TGM7 Homo sapiens Q96PF1
Validated Y2H
32296183
Intra
ARID5A Q03989 HDAC7 Homo sapiens Q8WUI4-6
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
Intra
ARID5A Q03989 RBFOX1 Homo sapiens Q9NWB1-5
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 RBFOX1 Homo sapiens Q9NWB1-5
Validated Y2H
32296183
Intra
ARID5A Q03989 RBFOX1 Homo sapiens Q9NWB1-5
Y2H Array
32296183
Intra
ARID5A Q03989 GATA5 Homo sapiens Q9BWX5
Validated Y2H
32296183
Intra
ARID5A Q03989 SOHLH1 Homo sapiens Q5JUK2
Validated Y2H
32296183
Intra
ARID5A Q03989 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 PRR20D Homo sapiens P86480
Y2H Array
32296183
Intra
ARID5A Q03989 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra
ARID5A Q03989 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra
ARID5A Q03989 ZNF765 Homo sapiens Q7L2R6-2
Validated Y2H
32296183
Intra
ARID5A Q03989 UBTD2 Homo sapiens Q8WUN7
Validated Y2H
32296183
Intra
ARID5A Q03989 CAMK2A Homo sapiens Q9UQM7
Validated Y2H
32296183
Intra
ARID5A Q03989 CAMK2A Homo sapiens Q9UQM7
Y2H Array
32296183
Intra
ARID5A Q03989 CAMK2A Homo sapiens Q9UQM7
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
ARID5A Q03989 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 KRTAP7-1 Homo sapiens Q8IUC3
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
Intra
ARID5A Q03989 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra
ARID5A Q03989 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
ARID5A Q03989 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
ARID5A Q03989 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
ARID5A Q03989 RNF44 Homo sapiens Q7L0R7
Validated Y2H
32296183
Intra
ARID5A Q03989 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra
ARID5A Q03989 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra
ARID5A Q03989 DOK6 Homo sapiens Q6PKX4
Validated Y2H
32296183
Intra
ARID5A Q03989 INIP Homo sapiens Q9NRY2
Validated Y2H
32296183
Intra
ARID5A Q03989 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
Intra
ARID5A Q03989 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra
ARID5A Q03989 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
ARID5A Q03989 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra
ARID5A Q03989 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra
ARID5A Q03989 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
ARID5A Q03989 TSEN15 Homo sapiens Q8WW01
Validated Y2H
32296183
Intra
ARID5A Q03989 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ARID5A Q03989 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
ARID5A Q03989 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra
ARID5A Q03989 ATP6V0D2 Homo sapiens Q8N8Y2
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra
ARID5A Q03989 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
ARID5A Q03989 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
ARID5A Q03989 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
Intra
ARID5A Q03989 CKS1B Homo sapiens P61024
Y2H Array
25416956
Intra
ARID5A Q03989 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
ARID5A Q03989 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
ARID5A Q03989 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
ARID5A Q03989 ODAM Homo sapiens A1E959
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 ODAM Homo sapiens A1E959
Y2H Array
32296183
Intra
ARID5A Q03989 MIEN1 Homo sapiens Q9BRT3
Validated Y2H
32296183
Intra
ARID5A Q03989 MAB21L2 Homo sapiens Q9Y586
Validated Y2H
32296183
Intra
ARID5A Q03989 MYLIP Homo sapiens Q8WY64
Validated Y2H
32296183
Intra
ARID5A Q03989 PIN1 Homo sapiens Q13526
Validated Y2H
32296183
Intra
ARID5A Q03989 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
ARID5A Q03989 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
ARID5A Q03989 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
ARID5A Q03989 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ARID5A Q03989 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra
ARID5A Q03989 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ARID5A Q03989 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
ARID5A Q03989 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
Intra
ARID5A Q03989 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
ARID5A Q03989 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
ARID5A Q03989 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
Intra
ARID5A Q03989 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
ARID5A Q03989 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra
ARID5A Q03989 PLA2G10 Homo sapiens O15496
Y2H Array
32296183
Intra
ARID5A Q03989 PLA2G10 Homo sapiens O15496
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra
ARID5A Q03989 RBPMS Homo sapiens Q93062-3
Validated Y2H
32296183
Intra
ARID5A Q03989 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
ARID5A Q03989 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra
ARID5A Q03989 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
ARID5A Q03989 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
ARID5A Q03989 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Intra
ARID5A Q03989 BAHD1 Homo sapiens Q8TBE0
Validated Y2H
32296183
Intra
ARID5A Q03989 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
ARID5A Q03989 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
ARID5A Q03989 TENT5D Homo sapiens Q8NEK8
Validated Y2H
32296183
Intra
ARID5A Q03989 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
Intra
ARID5A Q03989 ESR1 Homo sapiens P03372
Anti Bait CoIP
15941852
Intra
ARID5A Q03989 ESR1 Homo sapiens P03372
Y2H
15941852
Intra
ARID5A Q03989 ESR1 Homo sapiens P03372
Pull Down
15941852
Intra
ARID5A Q03989 SMYD1 Homo sapiens Q8NB12
Validated Y2H
32296183
Intra
ARID5A Q03989 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Intra
ARID5A Q03989 ZNF503 Homo sapiens Q96F45
Validated Y2H
32296183
Intra
ARID5A Q03989 LASP1 Homo sapiens Q14847-2
Validated Y2H
32296183
Intra
ARID5A Q03989 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
ARID5A Q03989 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
23275563
Intra
ARID5A Q03989 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
Intra
ARID5A Q03989 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Currarino Syndrome

  • Currarino Triad

  • Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation

  • CURRAS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00973 ARID5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARID5A VGNC VGNC:59918
Bos taurus ARID5A VGNC VGNC:26131
Mus musculus ARID5A MGD MGI:2443039
Rattus norvegicus ARID5A RGD RGD:1311041
Canis familiaris ARID5A VGNC VGNC:38100
Macaca mulatta ARID5A VGNC VGNC:69853
Others ARID5A NCBI