INIP - INTS3 and NABP interacting protein Gene

Also Known as MISE; SOSSC; SSBIP1; C9orf80; HSPC043; hSSBIP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58493

About INIP

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:112,683,926-112,718,117 (from NCBI)

This gene has 6 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in lymph node (RPKM 8.2), colon (RPKM 6.8) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]

INIP Products (7)

mRNA Protein Name
NM_001329585.2 NP_001316514.1 SOSS complex subunit C isoform b
NM_001329586.2 NP_001316515.1 SOSS complex subunit C isoform c
NM_001329587.2 NP_001316516.1 SOSS complex subunit C isoform d
NM_001329588.2 NP_001316517.1 SOSS complex subunit C isoform e
NM_001329589.2 NP_001316518.1 SOSS complex subunit C isoform e
NM_001329590.2 NP_001316519.1 SOSS complex subunit C isoform e
NM_021218.3 NP_067041.1 SOSS complex subunit C isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19683501 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
19683501 GOA
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
19605351 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
19683501 GOA
involved in mitotic G2/M transition checkpoint IDA
IDA: Inferred from direct assay
19683501 GOA
involved in response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
19605351 GOA
Cellular Component GO Annotation Evidence References Source
part of SOSS complex IDA
IDA: Inferred from direct assay
18449195 GOA
part of SOSS complex IPI
IPI: Inferred from physical interaction
19683501 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19605351 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
19683501 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SOSS complex subunit C

  • SSB-interacting protein 1

INIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INIP Q9NRY2 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
INIP Q9NRY2 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
INIP Q9NRY2 INTS3 Homo sapiens Q68E01
Anti Bait CoIP
19683501
Intra
INIP Q9NRY2 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
INIP Q9NRY2 DGCR6L Homo sapiens Q9BY27
MAPPIT
32296183
Intra
INIP Q9NRY2 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra
INIP Q9NRY2 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra
INIP Q9NRY2 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
INIP Q9NRY2 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Narcissistic Personality Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06817 INIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus INIP VGNC VGNC:102940
Rattus norvegicus INIP RGD RGD:1307983
Mus musculus INIP MGD MGI:1913459
Bos taurus INIP VGNC VGNC:30204
Canis familiaris INIP VGNC VGNC:49804
Others INIP NCBI